RNA editing


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RNA editing

[¦är¦en¦ā ′ed·əd·iŋ]
(cell and molecular biology)
Alteration in the nucleotide sequence of messenger RNA after it has been transcribed from DNA, changing the nature of its protein product from what was encoded; may entail insertion, deletion, or enzyme-catalyzed chemical alteration of nucleotides.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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After further analysis, the team unexpectedly found that GUN1 partners with another protein, MORF2 (an essential component of the plant RNA editing complex), to affect the efficiency of RNA editing during chloroplast-to-nucleus communication in damaged chloroplasts.
After the phenomenon of RNA editing came to light a few years ago, advances have been made in using NGS technology to start identifying some of these sites in the human genome where this process occurs.
This process, called RNA editing, is an extremely rare exception in most animal groups, but among coeloid cephalopods, this seems to be widespread.
Trypanosome U-deletional RNA editing involves guide RNA-directed endonuclease cleavage, terminal U exonuclease, and RNA ligase activities.
Furthermore, we conclude that the described sensitivity of the trypanosomal in vitro RNA editing system [24] cannot be attributed to the structure of the preedited substrate mRNAs, which suggests that the catalytic machinery that is the editosome might be sensitive to volume exclusion conditions.
In addition, the RNA editing site (AAAAGG) for the processing of V and W proteins conserved in the phosphoprotein gene sequences of Hendra virus and Nipah virus was found, and 6 conserved domains within the L proteins of the order Mononegavirales (8) were found in the MojV L protein.
Six percent of human miRNAs show RNA editing (IsomiRs), the site-specific modification of RNA sequences, to yield products different from those encoded by this DNA, which increases the diversity and scope of miRNA action beyond that implicated from the genome alone.
The discovery of RNA editing 25 years ago revealed a new layer of genetic information that provides organisms flexibility to explore sequence space that is not readily accessible through DNA mutations.
RNA editing of the microRNA-151 precursor blocks cleavag by the Dicer-TRBP complex.
The described RNA editing process, which occurs in the context of human and other primate specific sequences, also underscores the importance of addressing inflammation as "an essential driver of cancer relapse and therapeutic resistance," Jamieson said.
This process is intimately linked with ncRNA expression and is another epigenetic process, RNA editing, a mechanism for altering nucleotides in RNA molecules that allows the generation of significant diversity of transcripts in a highly environmental-responsive manner.

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