Racemase


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racemase

[′ras·ə‚mās]
(biochemistry)
Any of group of enzymes that catalyze racemization reactions.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Racemase

 

any one enzyme of the isomerase class that catalyzes the reversible interconversions of stereoisomers having one asymmetric carbon atom. Racemases include the enzymes that catalyze the interconversion of L- and D-amino acids, Land D-hydroxy acids, and the derivatives of these acids; for example, the interconversion of L- and D-alanine is catalyzed by alanine racemase, and the interconversion of L- and D-lactic acid by lactate racemase.

The racemases of amino acids are conjugated proteins having pyridoxal phosphate as the coenzyme. Thus far, the bacterial racemases of alanine, methionine, proline, glutamic acid, lysine, and threonine having been the most carefully studied. The racemase of lysine is used in the industrial production of L-lysine.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Expression of Alpha-Methylacyl-Coenzyme A Racemase in Nephrogenic Adenoma.
The role of alpha-methylacyl-CoA racemase in bile acid synthesis.
Genetic variations of a-Methylacyl-CoA Racemase are associated with sporadic prostate cancer risk in ethnically homogenous Koreans.
However, this hypothesis does not consider alternative sources of D-serine like microglia, in which both serine racemase and D-serine are also found.
Keywords: Alphamethylacyl-CoA racemase (AMACR), Adenocarcinoma prostate, Immunohistochemistry.
The most common adenocarcinomas metastatic to the bladder are from the prostate, therefore, markers PSA (prostate specific antigen) and AMACR (alpha-methylacyl-CoA racemase) which are positive for prostate origin, were performed.
According to Roche, elevated expression of p504s, which is also known as ?-methylacyl-CoA racemase (AMACR), has become a useful biomarker in the diagnosis of prostate adenocarcinoma1.
The immunostaining results were almost the same as the first specimen: SMA (+), CD117 (+) (1+) 100%, CD34 diffuse (+) 100%, smoothelin (-) some isolated cells, [alpha]-methylacyl coenzyme A racemase (-), Keratin AE1/AE3 mildly-focal (+), S100 (-), estrogen and progesterone receptor (-), desmin focal (+).
Three unique proteins involved in peptidoglycan biosynthesis within Salmonella Poona species were found to be inhibited by drugs, namely, alanine racemase, UDP-N-acetyl glucosamine 1-carboxyvinyltransferase and penicillin-binding protein 2.
Cook, "Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase," Microbiology, vol.
LCNEC is strongly positive for CD56, CD57, Chromogranin A, synaptophysin, and P504S/alpha methylacyl CoA racemase. Unfortunately as previous investigations and treatment for his prostate cancer were performed in another tertiary oncology unit, we could not get histological images for this publication.