clinical trial

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clinical trial

[¦klin·i·kəl ′trīl]
(medicine)
A research study used to find better ways to treat individuals with a specific disease, patients are evaluated after being administered a new treatment or drug.
References in periodicals archive ?
Some observational studies have pointed to an association between higher consumption of fish and lower risks of coronary artery disease and stroke, but more rigorous, randomized trials have not supported this link.
This was a rigorous and well-executed double-blind, double-placebo-controlled randomized trial. By utilizing broad inclusion criteria and enrolling patients both with and without previous exposure to anticholinergic medications, the generalizability of study findings are greatly improved.
Randomized trial comparing iridium implant plus external-beam radiation therapy with external beam radiation therapy alone in node-negative locally advanced cancer of the prostate.
Data Source: Data are from a randomized trial of 75 patients conducted to determine the impact of the binder on postoperative morphine use, pain, and ambulation in the first 24 hours after abdominal gynecologic surgery.
We are proud that our investments in randomized trials such as Horizons-AMI have led to the approval of products to treat a broader range of patients with coronary artery disease."
The investigators found that none of the randomized trials compared radiation therapy with active surveillance, or watchful waiting, in which patients with prostate cancer have no treatment and undergo close observation.
In the first-ever randomized trial, 24 Kawasaki disease patients with persistent or recrudescent fever 2-7 days after initial treatment with WIG at 2 g/kg, plus aspirin, were assigned to second-line therapy with either a second dose of IVIG or infliximab at 5 mg/kg given intravenously over 2 hours at six participating U.S.
In this issue of the Report, James Sabin and colleagues consider the ethics of conducting randomized trials in health plans to compare the effectiveness of drugs approved by the Food and Drug Administration that are considered to be in clinical equipoise--there is no consensus among experts that one drug is superior to the others.
Every randomized trial is not a single statistical analysis in isolation.
Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA.
Docosahexaenoic acid supplementation in vegetarians effectively increases omega-3 index: a randomized trial. Lipids 40:807-14.
(1.) Artz L et al., A randomized trial of clinician-delivered interventions promoting barrier contraception for sexually transmitted disease prevention, Sexually Transmitted Diseases, 2005, 32(11):672-679.

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