A vaccine is then prepared that mimics a section of the individual's specific mutated RAS protein
The antibody used is a polyclonal anti-ras and recognize all Ras proteins
In certain types of cancers, such as pancreatic, non-small cell lung and colorectal cancers, the mutation of the Ras protein
occurs frequently occurs and causes tumor cell proliferation.
Without the enzyme, the mutant Ras protein
can't instruct a cell to embark on a path of explosive growth.
In unfertilized frog eggs, the group observed that human oncogenic ras -- a rare, mutant relative of the normal ras protein
found in cells -- caused breakdown of the envelope surrounding the cell nucleus, indicating the protein induced cell division.
Salirasib is the first targeted molecule to demonstrate an ability to reduce total Ras protein
levels (both wild-type and mutated) in primary human tumors.
The GI-4000 series consists of three products (GI-4014, GI-4015, and GI-4016) directed to five specific mutations in the Ras protein
The ras protein
must be modified by the enzyme farnesyltransferase so that the protein can localize to the inner surface of the cell's membrane and function as a signal transmitter.
After its synthesis, ras protein
undergoes several modifications that facilitate its attachment to the inner surface of the cell's outer membrane.
Merck is using gene biology to develop compounds that inhibit the activation of oncogenes by a process involving the RAS protein
which is associated with many tumors.
A post-translational modification of the ras protein
(farnesylation) is required for ras function.