Researchers at the University of Illinois have been able to study precisely how Ras proteins
interact with cell membrane surfaces.
expression was significantly upregulated in the placenta obtained from obese pregnant women when compared to placenta obtained from lean pregnant women (Figure 1(a)).
As effectors of Ras proteins
have RBD domain, through which interact with Ras protein
Devos et al., "Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins
," Science, vol.
Sander, "The ras protein
family: evolutionary tree and role of conserved amino acids," Biochemistry, vol.
Ras protein-specific guanine nucleotide-releasing factor 2 (RASGRF2) is a Ras signaling protein  which regulates conversion of active/inactive forms of Ras proteins
. Our results show a decreased expression of RASGRF2 in ALN treated cells.
A vaccine is then prepared that mimics a section of the individual's specific mutated RAS protein
Found in 30 percent of all human cancer tumours, the Ras protein
literally 'drives cells crazy,' says Prof.
Induction of ras protein
was analysed by Western blotting.
In a study by Anderson et al, the incidence of ras mutation and human papillomavirus DNA detection was twice as high in verrucous cancer as compared to oral squamous cell carcinoma. Previous studies have also shown that the Ras gene product showed differences of expression in verrucous carcinoma versus squamous cell carcinoma.[8,9] In the study by Freer et al, normal mucosa and verrucous carcinoma showed significant expression of p21 Ras protein
, but a marked decrease in the detectable amounts of this protein in more undifferentiated cells.
The TAU researchers are trying to discover the mechanisms whereby the Ras protein
is transferred, and their initial findings seem to be promising.