Ras protein


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Related to Ras protein: GTPase, G protein

Ras protein

[¦är¦ā′es ‚prō‚tēn]
(cell and molecular biology)
A GTPase that is part of a signaling cascade that controls cell growth; it turns itself off by hydrolyzing guanosine triphosphate (GTP) to guanosine diphosphate (GDP); however, if left in its active (GTP-bound) form, it can lead to uncontrollable cell growth, or cancer.
References in periodicals archive ?
Researchers at the University of Illinois have been able to study precisely how Ras proteins interact with cell membrane surfaces.
Ras protein expression was significantly upregulated in the placenta obtained from obese pregnant women when compared to placenta obtained from lean pregnant women (Figure 1(a)).
As effectors of Ras proteins have RBD domain, through which interact with Ras protein.
Devos et al., "Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins," Science, vol.
Sander, "The ras protein family: evolutionary tree and role of conserved amino acids," Biochemistry, vol.
Ras protein-specific guanine nucleotide-releasing factor 2 (RASGRF2) is a Ras signaling protein [49] which regulates conversion of active/inactive forms of Ras proteins. Our results show a decreased expression of RASGRF2 in ALN treated cells.
ORFX was predicted in the literature as sharing a similar fold (LOOPP program (Tobi & Elber, 2000) than the human oncogene ras protein (PDB code 6Q21).
A vaccine is then prepared that mimics a section of the individual's specific mutated RAS protein.
Found in 30 percent of all human cancer tumours, the Ras protein literally 'drives cells crazy,' says Prof.
In a study by Anderson et al,[7] the incidence of ras mutation and human papillomavirus DNA detection was twice as high in verrucous cancer as compared to oral squamous cell carcinoma.[7] Previous studies have also shown that the Ras gene product showed differences of expression in verrucous carcinoma versus squamous cell carcinoma.[8,9] In the study by Freer et al,[8] normal mucosa and verrucous carcinoma showed significant expression of p21 Ras protein, but a marked decrease in the detectable amounts of this protein in more undifferentiated cells.
The TAU researchers are trying to discover the mechanisms whereby the Ras protein is transferred, and their initial findings seem to be promising.