rate-determining step

(redirected from Rate limiting step)
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rate-determining step

[′rāt di¦tər·mən·iŋ ‚step]
(chemistry)
In a multistep chemical reaction, the step with the lowest velocity, which determines the rate of the overall reaction.
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According to the concept of Zhang and Van Etten [30] if the rate limiting step is the formation of phosphoenzyme intermediate, then the acceptor molecule (A) reacts with phosphoenzyme, it will not increase the overall rate of breakdown of substrate.
It has become clear in the field of RNAi that delivery is the rate limiting step.
Elixir's Vice President of Medical Development and first author of the study, commented, "The known activity of MTP, as a rate limiting step in lipid metabolism, lends functional credibility to our association of MTP with human longevity.
Our particular strength lies in the identification and quantification of transport proteins involved in membrane permeation at the cellular level combined with our expertise in quantifying the rate limiting steps of translocation at atomic level.
The novel aspect here is to use state-in-the art techniques to quantify rate limiting steps of individual components involved antibiotic penetration and to validate them at the cellular level.