rate-determining step

(redirected from Rate-limiting enzyme)
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rate-determining step

[′rāt di¦tər·mən·iŋ ‚step]
(chemistry)
In a multistep chemical reaction, the step with the lowest velocity, which determines the rate of the overall reaction.
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References in periodicals archive ?
SSAT is a key rate-limiting enzyme in mammalian polyamine catabolism, which can be induced by various stimuli, like natural polyamines, polyamine analogues, hormones and cytokines, drugs, and so on [45-47].
The D6-desaturase is the rate-limiting enzyme involved in HUFAs biosynthesis, which is responsible for the first step in the desaturation/elongation process in HUFAs synthesis.
GAD is the rate-limiting enzyme for the neurotransmitter gamma-aminobutyric acid (GABA).
"LX1031 acts locally on enterochromaffin cells in the GI tract to inhibit tryptophan hydroxylase, the rate-limiting enzyme in the synthesis of serotonin," explained Dr.
Rate-limiting enzyme: The slowest step in the creation of a molecule, and often the most important, because it requires additional energy and is highly regulated.
The successful pairing of aliskiren with the diuretic hydrochlorothiazide was seen as a step forward for this agent--the first from a novel drug class--because it showed evidence of blocking renin, the rate-limiting enzyme of the renin-angiotensin-aldosterone system.
The mechanism(s) of such effects remains unknown and may be diverse but could include effects on DA release, on the DA transporter, and/or on the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in the DA synthesis pathway (Dluzen and McDermott 2000; Kuppers et al.
Glycogen synthase kinase (GSK3) regulates glycogen synthase, the rate-limiting enzyme in glycogen synthesis.
Immunoreactive antibodies directed against GABA and its rate-limiting enzyme glutamic acid decarboxylase (GAD) indicate that horizontal cells of the skate are most likely GABAergic (1).
Both technologies are based on significant new discoveries around the function and regulation of ACCase, a key rate-limiting enzyme involved in oil production.
We investigated whether the age-related impairment of cardiac fatty acid catabolism occurs, at least partially, through diminished levels of L-carnitine, which would adversely affect carnitine palmitoyltransferase 1 (CPT1), the rate-limiting enzyme for fatty acyl-CoA uptake into mitochondria for beta]-oxidation.

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