rate-determining step

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rate-determining step

[′rāt di¦tər·mən·iŋ ‚step]
(chemistry)
In a multistep chemical reaction, the step with the lowest velocity, which determines the rate of the overall reaction.
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References in periodicals archive ?
Diffusion into the product layer was, therefore, the rate-limiting step of the process.
The metalcasting facility has processed 24 heats in one day on occasion, but rate-limiting steps begin to appear, and often other departments cannot keep up with this pace unless under near perfect conditions.
Given that tyrosine hydroxylase is the rate-limiting step in catecholamine synthesis, staining for tyrosine hydroxylase will be supportive of the diagnosis.
The study findings demonstrate that the amide bond cleavage is due to intramolecular nucleophilic catalysis by the adjacent carboxylic acid group and the rate-limiting step is the dissociation of the tetrahedral intermediate (Figure 4) 38].
So, the third obstacle, evidence-based interpretation, is not really the rate-limiting step today.
Cardiac myosin activators are thought to accelerate the rate-limiting step of the myosin enzymatic cycle and shift the enzymatic cycle in favor of the force-producing state, concluded the companies.
"The rate-limiting step with the current set-up is moving elderly patients in and out of a single room as this limits the number of injections we can give to around 10 per session where, potentially, we could progress to 40 per session."
"Preparation of the ultra thin samples required by TEM is the rate-limiting step in this analysis.
This result clearly supports our suggestion that degradation of peptide to AA may be the rate-limiting step in protein degradation in the rumen (Choi et al., 2002a, 2002b; Oh et al., 2008).
This creates a compressive strain on the surface platinum atoms, making the platinum more active in the rate-limiting step of oxygen reduction reaction for the fuel cell.
Once a product candidate is selected for clinical development, production of material for human clinical trials is the rate-limiting step. The Chemistry, Manufacturing, and Control (CMC) activities that are needed to develop a manufacturing process and associated quality control test methods can require up to two years to complete.

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