Summary: A base-catalyzed one pot reaction has been developed for the synthesis of 2-(1H-indol-3-yl)- acetamides via coupling of 1,1-carbonyldiimidazole with 2-(1H-indol-3-yl) acetic acid resulting in the formation of a reactive intermediate
which on treatment with different substituted anilines afford 2-(1H- indol-3-yl)-acetamides in good yield.
Metabolism/clearance studies assess a drug candidate's stability in microsomes/hepatocytes; and human cytochromes P450 (CYP) isoform involvement, inhibition, induction and reactive intermediate
Enzyme-free reduction of nitro-aromatic compounds and the sequence of reactions in the reduction of nitro functional group result in the formation of very highly reactive intermediate
Biological Reactive Intermediate
Conference VII: BRIs and Human Health and Disease.
The nature of this reactive intermediate
is unknown at present.
A key is to monitor the excited states and the reactive intermediate
species formed upon absorption of a photon.
ALCATTEAL is used as a co-catalyst in the production of polyethylene and polypropylene, and also as a reactive intermediate
in the manufacturing of linear alpha olefins (LAO).
Chemistry, edited by Platz, looked at the chemistry of reactive intermediates
commonly encountered in mechanistic organic chemistry, and the 10 studies here expand the coverage to include intermediates centered on silicon, germanium, and tin; tetrahedral intermediates; and such topics as quantum mechanical tunneling, conical intersections, and combustion chemistry.
To understand the exposure-response relationship, it is necessary to understand the relationship between environmental concentrations of a compound and a measure of body burden or a biomarker that can be a reactive intermediate
, a stable metabolite, or a macromolecular adduct.
Chromate reduction is accompanied by the generation of highly reactive Cr(V), a reactive intermediate
, and reactive oxygen intermediates which can cause DNA damage including intra- and interchromosomal deletions and base substitutions.
14]C]DDE to a reactive intermediate
that becomes irreversibly bound in the zona fasciculata cells.
The development of a photocatalytic model system is proposed, which will be tailored by molecular synthetic protocols and optimized by solid-state chemical procedures and crystal engineering so as to provide insights into the architectures, reactive intermediates
and mechanistic steps involved in the photocatalytic process, with complementary insights from theory.