Reformatsky Reaction

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Reformatsky reaction

[‚rif·ər′mat·skē rē‚ak·shən]

(organic chemistry)

A condensation-type reaction between ketones and α-bromoaliphatic acids in the presence of zinc or magnesium, such as R₂CO + BrCH₂·COOR + Zn → (ZnO·HBr) + R₂C(OH)CH₂COOR.

Reformatsky Reaction

the synthesis of the esters of β-hydroxy carboxylic acids (II) through the interaction of aldehydes or ketones with the esters of α-halo carboxylic acids (I) in the presence of metallic zinc. The X in these reactions represents a halogen, and the R an organic radical:

The reaction was discovered by S. N. Reformatskii (S. N. Reformatsky) in 1887 and is today used in organic chemistry for the preparation of certain substances.

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References in periodicals archive ?

3-OH-FAs, both natural and isotope-labeled compounds, were synthesized using the Reformatsky reaction (20).

Improved stable isotope dilution-gas chromatography-mass spectrometry method for serum or plasma free 3-hydroxy-fatty acids and its utility for the study of disorders of mitochondrial fatty acid [beta]-oxidation