Regulus


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Regulus

(Marcus Atilius Regulus) (rĕg`yo͝oləs), d. c.250 B.C., Roman general in the First Punic War. While consul (267 B.C.) he conquered the Sallentini and captured Brundisium (now Brindisi). He became consul a second time (256), defeated the Carthaginians at sea, and waged war against them in Africa, at first with success. Soon afterward the Carthaginians won a complete victory and captured (255) Regulus. He was sent on parole to solicit peace from the Romans, but instead he advised the senate against accepting the Punic terms or exchanging prisoners. Resisting persuasions to break his parole, he returned to Carthage, where he was supposedly tortured to death. The story made Regulus famous as a Roman patriot-martyr.

Regulus

(rĕg`yələs), brightest star in the constellation LeoLeo
[Lat.,=the lion], northern constellation lying S of Ursa Major and on the ecliptic (apparent path of the sun through the heavens) between Cancer and Virgo; it is one of the constellations of the zodiac.
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; Bayer designation Alpha Leonis; 1992 position R.A. 10h08m, Dec. +12°00'. A bluish-white main-sequence star of spectral classspectral class,
in astronomy, a classification of the stars by their spectrum and luminosity. In 1885, E. C. Pickering began the first extensive attempt to classify the stars spectroscopically.
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 B7 V, its apparent magnitudemagnitude,
in astronomy, measure of the brightness of a star or other celestial object. The stars cataloged by Ptolemy (2d cent. A.D.), all visible with the unaided eye, were ranked on a brightness scale such that the brightest stars were of 1st magnitude and the dimmest stars
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 of 1.35 makes it one of the 25 brightest stars in the sky. Its distance from the earth is about 85 light-years. Regulus is a visual triple star. Its name is Latin for "prince."

Regulus

(reg -yŭ-lŭs) (α Leo) A bluish-white star that is the brightest one in the constellation Leo and lies at the base of the Sickle of Leo. It is a visual triple star, with the bright Regulus A being accompanied by an orange companion (B) orbiting A once every 130 000 years at a distance of more than 4000 AU. B itself has a 13th-magnitude red dwarf companion (C). The Regulus system has a common proper motion with a fourth star (D). mv : 1.4 (A), 7.7 (B); Mv : –0.3; spectral type: B7 V (A), K1 V (B); distance: 21 pc.

regulus

[′reg·yə·ləs]
(metallurgy)
Impure metal formed beneath the slag during smelting or reduction of ores.

Regulus

[′reg·yə·ləs]
(astronomy)
A star of stellar magnitude 1.34, about 67 light-years from the sun, spectral classification B8, in the constellation Leo; the star α Leonis. Also known as Little Ruler.
(ordnance)
A United States surface-to-surface, jet-powered guided missile; it is equipped with a nuclear warhead, and launched from a surfaced submarine or a cruiser.

Regulus

Marcus Atilius . died ?250 bc, Roman general; consul (267; 256). Captured by the Carthaginians in the First Punic War, he was sent to Rome on parole to deliver the enemy's peace terms, advised the Senate to refuse them, and was tortured to death on his return to Carthage
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Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including statements associated with the expected ability of Regulus to undertake certain activities and accomplish certain goals (including with respect to development and other activities related to RG-101 and RG-012), the projected timeline of clinical development activities, and expectations regarding future therapeutic and commercial potential of Regulus' business plans, technologies and intellectual property related to microRNA therapeutics and biomarkers being discovered and developed by Regulus.
For Regulus, though, the diameter at the equator is 3,700,000 miles, and the diameter at the poles is only 2,800,000 miles.
Green Star, Notos, and Sirius Regulus will collectively form a company in the Netherlands, a structure will give Green Star the best economic and tax benefits, the company said in a press release.
To find out more about Regulus, stop by Booth 310 at the MBA's [90.
Aker will be responsible for all legal, corporate, and intellectual property matters for Regulus.
RG-012 -- claims of the patents, owned solely by Regulus, cover the anti-miR-21 component of RG-012, as well as pharmaceutical compositions and methods of treatment of Alport syndrome using any one of a broad class of modified oligonucleotides complementary to miR-21.
Our studies with Regulus show that miR-33 specifically targets genes involved in HDL-C biogenesis, cholesterol efflux and fatty acid oxidation, and its antagonism results in direct upregulation of these pathways with clear potential for therapeutic benefit.
In August, Regulus initiated a Phase II study evaluating the efficacy of RG-101 when given in combination with marketed anti-HCV agents Harvoni, Olysio, and Daklinza for 28 days.
Neil brings to Regulus significant pharmaceutical research and development experience, further strengthening our management team and positioning the company to make significant progress in our drug development efforts," said Kleanthis G.
Neither Regulus nor GSK has any further obligations or commitments beyond the contemplated study under the clinical collaboration agreement.
Regulus undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.
published in Science last year and additional preclinical research performed in collaboration with Regulus have shown that antagonizing miR-33a and miR-33b with anti-miRs can have significant impact on HDL raising and atherosclerotic plaque reduction.