Relaxin


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relaxin

[ri′lak·sən]
(biochemistry)
A hormone found in the serum of humans and certain other animals during pregnancy; probably acting with progesterone and estrogen, it causes relaxation of pelvic ligaments in the guinea pig.

Relaxin

 

a hormone formed mainly in the ovaries that produces relaxation of the ligaments of the pubic symphysis of the pubic bones during pregnancy; as a result, the pelvis widens and normal childbirth is facilitated. Relaxin also characteristically inhibits the spontaneous contractions of the uterus.

Chemically relaxin is a polypeptide. Refined sow relaxin exhibits pronounced basic properties; it has molecular weight of about 6,500 and a structure of two subunits, consisting respectively of 22 and 28–31 amino-acid residues, joined by a disulfide bond. The primary structure has not been determined. The biosynthesis of either relaxin or the polypeptides that are closely related to it structurally is also possible in tissues found in the uterus and placenta.

References in periodicals archive ?
There's a huge change after your first child - physically and mentally you are a different person My body was used to being stiff like a coiled spring, so the pregnancy hormone relaxin really affected me
RLX, a two-chain peptide hormone, belongs to the relaxin peptide family, which is structurally similar to the insulin family.
Bussey, "Pregnancy-related pelvic girdle pain and its relationship with relaxin levels during pregnancy: a systematic review," European Spine Journal, vol.
Variations in serum relaxin (hRLX-2) concentrations during human pregnancy.
Relaxin: review of biology and potential role in treating heart failure.
Jeong et al., "Relaxin augments BMP 2-induced osteoblast differentiation and bone formation," Journal of Bone and Mineral Research, vol.
Kaminska et al., "Assessment of VEGF-receptor system expression in the porcine endometrial stromal cells in response to insulin-like growth factor-I, relaxin, oxytocin and prostaglandin E2," Molecular and Cellular Endocrinology, vol.
In the biomarker analysis from the Relaxin in acute heart failure (RELAX-AHF) development program [16], changes in markers of cardiac (hsTnT), renal (pCr and cystatin-C), and hepatic (aspartate transaminase and alanine transaminase) damage and of decongestion (NTproBNP) at day 2 improved with Serelaxin administration.
McTiernan et al., "Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts," Circulation Research, vol.
THANK YOU DISTRICT 1 for your "Relaxin Memphis Style" basket.