Releasing Factor


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Releasing Factor

 

(also releasing hormone), one of a group of neurohormones formed in the hypothalamus that act on the cells of the anterior lobe of the pituitary gland and stimulate or inhibit the secretion of tropic hormones into the blood. Extracts from the hypothalamus of humans and many vertebrate animals have been shown to contain specific releasing factors that stimulate the pituitary gland to release adrenocorticotropic hormone, luteinizing hormone, thyrotropin, folliclestimulating hormone, growth hormone, melanocyte-stimulating hormone, and prolactin. Releasing factors that inhibit the secretion of prolactin, melanocyte-stimulating hormone, and growth hormone have also been isolated.

All releasing factors appear to be peptides. For example, the releasing factor that stimulates the secretion of thyrotropin is a tripeptide—pyroglutamylhistidylpropylamide. This factor has been synthesized and is now used in medicine to detect local disorders of the hypothalamus, pituitary, and thyroid glands.

REFERENCES

Iudaev, N. A., and Z. F. Evtikhina. “Sovremennye predstavleniia o gipotalamicheskikh rilizing-faktorakh.” In Sovremennye voprosy endokrinologii, fase. 4. Moscow, 1972.
“Hypophysiotropic Hormones of the Hypothalamus: Assay and Chemistry.” Proceedings of the Workshop Conference…. Baltimore, 1970.

V. M. SAMSONOVA

References in periodicals archive ?
Corticotropin releasing factor signaling in colon and ileum: regulation by stress and pathophysiological implications.
Novel agents as CRF (Corticotrophin Releasing Factor) antagonists can reduce the high levels ofCRF in blood in anxiety disorders, depression, anorexia nervosa and posttraumatic or post-ischemic neuropsychiatric disorders.
The company also confirmed that it has requested a meeting with the Food and Drug Administration (FDA) in the United States to discuss advancing ThGRF (TH9507), an analogue of growth hormone releasing factor, into late-stage development.
The Salk Institute for Biological Studies (La Jolla, CA) has patented a G-protein-coupled receptor proteins (CRF-R) characterized by having sufficient binding affinity for corticotropin releasing factor (CRF) such that concentrations of 10 nM of CRF occupy 50% of the binding sites of said receptor protein.
Stress increases Corticotropin Releasing Factor (CRF) and Proopiomelanocortin (POCM) release.
Note: CRF - corticotropin releasing factor; TRH - thyrotropin releasing hormone; GHRF - growth hormone releasing factor, SOM-somatostatin; ACTH-adrenocorticotropin; GH - growth hormone; LH - leutinizing hormones; FSH - follicle-stimulating hormone; PRL - prolactin; NK - natural killer cell; IFN - interferon; IL - interleukin
A role for corticotropin releasing factor (CRF) in ethanol consumption, sensitivity, and reward as revealed by CRF-deficient mice.
Theratechnologies submitted an NDA to the FDA on 29 May 2009, for tesamorelin, an analogue of the growth hormone releasing factor, proposed for the treatment of excess abdominal fat in HIV-infected patients with lipodystrophy.
Central regulation of gastric emptying of solid nutrient meals by corticotropin releasing factor. Neurogastroenterol.
Consumption of alcohol also may alter regulatory agents of stress, particularly increasing corticotropin releasing factor (CRF) activity and decreasing neuropeptide Y.
The name's initial letters also reference ghrelin's role as a growth hormone releasing factor.