Releasing Factor

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Releasing Factor


(also releasing hormone), one of a group of neurohormones formed in the hypothalamus that act on the cells of the anterior lobe of the pituitary gland and stimulate or inhibit the secretion of tropic hormones into the blood. Extracts from the hypothalamus of humans and many vertebrate animals have been shown to contain specific releasing factors that stimulate the pituitary gland to release adrenocorticotropic hormone, luteinizing hormone, thyrotropin, folliclestimulating hormone, growth hormone, melanocyte-stimulating hormone, and prolactin. Releasing factors that inhibit the secretion of prolactin, melanocyte-stimulating hormone, and growth hormone have also been isolated.

All releasing factors appear to be peptides. For example, the releasing factor that stimulates the secretion of thyrotropin is a tripeptide—pyroglutamylhistidylpropylamide. This factor has been synthesized and is now used in medicine to detect local disorders of the hypothalamus, pituitary, and thyroid glands.


Iudaev, N. A., and Z. F. Evtikhina. “Sovremennye predstavleniia o gipotalamicheskikh rilizing-faktorakh.” In Sovremennye voprosy endokrinologii, fase. 4. Moscow, 1972.
“Hypophysiotropic Hormones of the Hypothalamus: Assay and Chemistry.” Proceedings of the Workshop Conference…. Baltimore, 1970.


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Decreased density of corticotropin releasing factor receptors in frontal cortex
Comparison of basal neuropeptide Y and corticotropin releasing factor levels between the high ethanol drinking C57BL/6J and low ethanol drinking DBA/2J inbred mouse strains.
In vitro and in vivo analysis of the effects of corticotropin releasing factor on rat dorsal vagal complex.
Corticotrophin releasing factor is a neurotransmitter that mediates physiological and behavioral responses to stress.
Corticotropin releasing factor (CRF), a neuropeptide, is known to be related to these physiological functions and neurological disorders.
Neurotransmitter modulation of corticotropin releasing factor secretion into the hypophysial-portal circulation.
Theratechnologies submitted an NDA to the FDA on 29 May 2009, for tesamorelin, an analogue of the growth hormone releasing factor proposed for the treatment of excess abdominal fat in HIV patients with lipodystrophy.
Neurobiologists have found that consumption of alcohol also may alter regulatory agents of stress, particularly increasing corticotropin releasing factor (CRF) activity and decreasing neuropeptide Y.
Rosenthal recommended doing a GnRH stimulation test, which is also called a luteinizing hormone releasing factor (LRF) stimulation test.
Effect of thyroxine replacement therapy on plasma insulin-like growth factor 1 levels and growth hormone responses to growth hormone releasing factor in hypothyroid patients.
The market scenario is expected to change after the launch of new therapies such as Alpha and Beta Adrenergic Receptor antagonists, N-methyl D-aspartate (NMDA) receptor modulators, Corticotropin Releasing Factor (CRF1) inhibitors, Progesterone receptor antagonist, V1 Receptor antagonists, and mGluR7 NAM inhibitor.
Central administration of corticotrophin releasing factor induces long-term sensitization to D-amphetamine.