In animal model, rapid atrial pacing has been reported to elevate plasma renin
activity (PRA) (8).
The body regulates blood pressure using a variety of compounds, including renin
, by changing the diameter of blood vessels.
Due to its effects on the renin
feedback system, it cannot be used with an ACE inhibitor or an ARB.
cleaves angiotensin I (AI) from angiotensinogen that is produced mainly by the liver.
Conclusion: Primary hyperaldosteronism as compared to other renin
angiotensin aldosterone system disorders was found to be the leading cause of hypertension in young population.
Briefly, experimental studies have shown elevated production of renin
and angiotensin II in vitamin D receptor (VDR) knockout mice, leading to hypertension and cardiac hypertrophy [4,5].
Blacks were much more likely to have a low plasma renin
, which at the time was attributed to primary aldosteronism, mostly due to bilateral adrenocortical hyperplasia (plasma aldosterone levels were then not available; therefore, the Liddle phenotype was unrecognised in that clinic population).
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The cause of both conditions is suggested to be the compression of the renal parenchyma by subcapsular collection, which results in increased erythropoietin and renin
secretion due to ischaemic kidney (page kidney).
Keywords: Neonatal Bartter syndrome, serum renin
, serum aldosterone, polyhydramnios
In fully adjusted models, log-plasma renin
activity was not associated with incident diabetes mellitus.
Primary aldosteronism is characterized by autonomous production of aldosterone by the adrenal glands along with suppressed renin
production by the renal juxtaglomerular apparatus.