lagging strand

(redirected from Replication fork)
Also found in: Dictionary, Thesaurus, Medical, Legal, Wikipedia.

lagging strand

[′lag·iŋ ‚strand]
(cell and molecular biology)
In deoxyribonucleic acid (DNA) replication, the 3′ to 5′ DNA strand that is discontinuously synthesized as a series of Okazaki fragments in the 5′ to 3′ direction.
Mentioned in ?
References in periodicals archive ?
Regulatory signaling mediated by the small modifier protein ubiquitin has a prominent role in orchestrating the reorganization of the replication fork necessary for overcoming DNA lesions, but this involvement has not been systematically explored.
The aim is to define how replication fork perturbation is detected and engaged by cellular stress-response factors, and then tolerated or repaired.