lagging strand

(redirected from Replication fork)
Also found in: Dictionary, Thesaurus, Medical, Legal, Wikipedia.

lagging strand

[′lag·iŋ ‚strand]
(cell and molecular biology)
In deoxyribonucleic acid (DNA) replication, the 3′ to 5′ DNA strand that is discontinuously synthesized as a series of Okazaki fragments in the 5′ to 3′ direction.
Mentioned in ?
References in periodicals archive ?
They also play a part in "sterilizing" replication forks that have stalled by treatment with DNA-damaging agents.
Each DNA lesion is recognized by specific sensor proteins according to the cell cycle phase in which the cell is; during S phase, the protein FANCM identifies a replication fork arrested by an ICL, MRN + BRCA1 sense DSBs; meanwhile, Ku70/Ku80 + 53BP1 can recognize DSBs across the entire interphase; RPA detects and covers ssDNA primarily during S phase.
These include: (i) Assuring that DNA replication stops when the converging replication forks reach specific chromosomal termination sites (ter sites); [sup][15] (ii) unlinking of the two interlocked DNA circles (catenanes) that are generated by the replication termination step [Figure 2]b; [sup][10] (iii) resolving the chromosomal dimers that are generated by recombinational crossover [Figure 2]c.
Diffley, "Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?" Current Opinion in Genetics and Development, vol.
Rolfsmeier et al., "Phosphorylation of Rad55 on serines 2, 8, and 14 is required for efficient homologous recombination in the recovery of stalled replication forks," Molecular and Cellular Biology, vol.