Resting Potential

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Related to Resting Potential: action potential

resting potential

[′rest·iŋ pə‚ten·chəl]
The potential difference between the interior cytoplasm and the external aqueous medium of the living cell.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Potential, Resting


a potential difference between the contents of a cell or fiber and the extracellular fluid; the difference in potential is localized on the surface membrane. The membrane’s inner surface is charged electronegatively with respect to the outer surface.

Resting potential results from unequal concentrations of Na+, K+, and Cl- ions on both sides of the cell membrane and from the membrane’s unequal permeability to these ions. In nerve and muscle cells, resting potential helps keep the membrane’s molecular structure ready for excitation in response to stimulation. All influences on a cell causing a prolonged and stable decrease in action potential result in decreased cell excitability or in total loss of the cell’s capacity to generate action potential. Such influences include metabolic disturbance, increase in extracellular content of K+ ions, and the effect of a strong electric current.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
First, let us assume that at the resting potential, the sum of all ionic currents ([Sigma][I.sub.j], in A [m.sup.-2]) is 0 A.
While the electrochemical potential of [Na.sup.+] will tend to drive [Na.sup.+] into the cell at the resting potential, it will cease to move passively into the cell once the potential depolarizes to -0.100 V and the electrochemical potential for [Na.sup.+] approaches 0 V.
The results show that the photoreceptors have cell resting potentials of about -49 [+ or -] 7 mV and respond to a flash of light with a depolarization consisting of a transient component, often accompanied by a burst of action potentials, followed by a steady-state or plateau depolarization.
In contrast, resting potentials and conduction velocities did exhibit significant seasonal variation.
In 17 neurons from 6 fish, resting potentials ranged from -56 to -71 mV (mean = -64.5), and evoked action potentials ranged in amplitude from 92-115 mV (mean = 103.7).
If oocytes had stable resting potentials after about 30 min in darkness, we perfused them with 20[mu]M 11-cis retinal for 45 min and tested them for light sensitivity.
Resting potentials are in the range of -45 to -60 mV.