Nplate administration may increase the risk for development or progression of reticulin
fiber formation within the bone marrow.
Histological analysis of the aorta in the late third trimester demonstrates that the reticulin
fibers of the aortic media, which provide structural maintenance to the vessel, become fragmented (8).
stain exhibited coarse fibre network.
Collagen is the connective tissue contributing to less tender meat, as elastin and reticulin
are found in much smaller amounts and do not appear to contribute to unfavorable tenderness (Bailey, 1972).
Some lesions were found in adult connective tissue, formed by mature collagen scar fibers (type I collagen) and few inflammatory cells, whereas other lesions had reticulin
fibers (type III collagen) with numerous inflammatory cells.
Proteases released from eosinophils (collagenase, peroxidase, acid phosphatase and major B protein) is responsible for fragmentation of reticulin
fibers in the arterial wall.
While a reticulin
stain was not used, overt fibrosis was assessed and was not prominent.
Slides of the peripheral blood and bone marrow aspirates were stained using Romanowsky and May-Grunwald Giemsa (MGG) stains respectively; the trephine biopsy was decalcified, fixed, embedded in wax, cut, trimmed and stained using haematoxylin and eosin (H&E), MGG and reticulin
A bone marrow biopsy revealed hypocellular bone marrow containing dense reticulin
fibers (grade 3).
Additionally, because the nodules cannot be visualized on routine H&E or trichrome staining, a special reticulin
stain must be performed to show the nodules clustered around the portal triads without fibrosis or collagen deposition, in contrast to alcoholic cirrhosis.
2) Many factors may contribute to the development of cytopaenias in HIV, including the virus itself that can infect progenitor cells directly, cytokine effects, reticulin
fibrosis, altered immune function with auto-antibody production, micro-nutrient deficiency (folate, vitamin [B.
A bone marrow biopsy performed on January 19 demonstrated 10% cellular marrow, staining negative for reticulin