retrosynthetic analysis


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retrosynthetic analysis

[‚re·trō·sin¦thed·ik ə′nal·ə·səs]
(organic chemistry)
A method for planning an organic chemical synthesis in which the desired product molecule is considered first, and then steps are considered one at a time leading back to the appropriate starting materials.
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In fact, one approach to organic synthesis known as retrosynthetic analysis, or "the disconnection approach," is also useful as a strategy for selecting the perfect cleaning process.
While developing software to enable computer-assisted synthetic accessibility and retrosynthetic analysis they support chemists through the challenges of organic synthesis.
The focus of most chapters is mechanistic and stereochemical, with the development of synthetic approaches in forward strategy and generality rather than retrosynthetic analysis, though the latter is not totally ignored.
Rather than taking a trial-and-error approach based largely on intuition, he and his co-workers developed a system of logical principles -- called retrosynthetic analysis -- to help in the rational planning of chemical syntheses.
One approach to organic synthesis is retrosynthetic analysis.
Together the workbook and textbook provide a complete course in retrosynthetic analysis.
Workbook for Organic Synthesis: The Disconnection Approach, 2nd edition, combined with the main textbook, provides a full course in retrosynthetic analysis for chemistry and biochemistry students, and a refresher course for organic chemists working in industry and academia.
The textbook and workbook together provide a complete course in retrosynthetic analysis for advanced organic students describes and illustrates the key concepts involved in how to use retrosynthetic analysis to design synthetic routes
Professor Corey is the recipient of the 1990 Nobel Prize in Chemistry for the development of retrosynthetic analysis, the methodology of organic synthesis that systematized the way chemists build the complicated molecules of life in the laboratory.
Approaches to synthesis have developed from early bases in analogy, association, and intuition to case study and retrosynthetic analysis, and molecules under study have become increasingly complex.
The text does, however, assume familiarity with the terminology of retrosynthetic analysis, and is concerned with relatively complex molecules.
Corey is the recipient of the 1990 Nobel Prize in Chemistry for the development of retrosynthetic analysis, the theory methodology of organic synthesis that systematized the way chemists build the complicated molecules of life in the laboratory.