retrosynthetic analysis


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retrosynthetic analysis

[‚re·trō·sin¦thed·ik ə′nal·ə·səs]
(organic chemistry)
A method for planning an organic chemical synthesis in which the desired product molecule is considered first, and then steps are considered one at a time leading back to the appropriate starting materials.
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From the retrosynthetic analysis of the target, two fragments where identified that will be prepared then connected in the last stage of the synthesis, following a biomimetic approach.
Chapters include experiments and general, theoretical, and mechanistic background and explanations, with special emphasis on retrosynthetic analysis and alternative approaches of synthesis for a given molecule.
The business, founded in 1996, specialises in the computer-aided retrosynthetic analysis segment, with its ARChem Route Designer system helping chemists design viable synthetic routes for target molecules.
In fact, one approach to organic synthesis known as retrosynthetic analysis, or "the disconnection approach," is also useful as a strategy for selecting the perfect cleaning process.
The focus of most chapters is mechanistic and stereochemical, with the development of synthetic approaches in forward strategy and generality rather than retrosynthetic analysis, though the latter is not totally ignored.
Rather than taking a trial-and-error approach based largely on intuition, he and his co-workers developed a system of logical principles -- called retrosynthetic analysis -- to help in the rational planning of chemical syntheses.
One approach to organic synthesis is retrosynthetic analysis.
Together the workbook and textbook provide a complete course in retrosynthetic analysis.
Workbook for Organic Synthesis: The Disconnection Approach, 2nd edition, combined with the main textbook, provides a full course in retrosynthetic analysis for chemistry and biochemistry students, and a refresher course for organic chemists working in industry and academia.
Approaches to synthesis have developed from early bases in analogy, association, and intuition to case study and retrosynthetic analysis, and molecules under study have become increasingly complex.
The text does, however, assume familiarity with the terminology of retrosynthetic analysis, and is concerned with relatively complex molecules.