Reye's syndrome


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Related to Reye's syndrome: black mass, aspirin

Reye's syndrome

(rīz), rare but life-threatening disease characterized by acute encephalopathy and fatty infiltration of internal organs, especially the liver. It occurs almost entirely in children under age 15. The cause is unknown, but the disease usually follows an acute viral infection (particularly influenza or chickenpox), especially when aspirinaspirin,
acetyl derivative of salicylic acid (see salicylate) that is used to lower fever, relieve pain, reduce inflammation, and thin the blood. Common conditions treated with aspirin include headache, muscle and joint pain, and the inflammation caused by rheumatic fever and
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 or other salicylates have been given. The symptoms, which occur about a week after the virus infection, are vomiting and disorientation; these may be followed by seizures, coma, and respiratory arrest. Treatment is directed toward reducing brain swelling, correcting blood chemistry changes due to liver damage, and providing respiratory support if needed. Doctors recommend that children be given acetaminophenacetaminophen
, an analgesic and fever-reducing medicine. It is an active ingredient in many over-the-counter medicines, including Tylenol and Midol. Introduced in the early 1900s, acetaminophen is a coal tar derivative that acts by interfering with the synthesis of
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 rather than aspirin for viral infections or feverfever,
elevation of body temperature above the normal level, which in humans is about 98°F; (37°C;) when measured orally. Fever is considered to be a symptom of a disorder rather than a disease in itself.
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.

Reye's syndrome

[′rīz ‚sin‚drōm]
(medicine)
An uncommon liver disorder primarily occurring in infants and young children; characterized by convulsions, hypoglycemia, and a liver showing diffuse microvacuolar fatty metamorphosis.
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References in periodicals archive ?
In the US, a total of 1 207 cases of Reye's syndrome were reported from 1981 to 1997.
The statement added: "There have been no confirmed cases of Reye's Syndrome associated with Bonjela or Bonjela Cool, which remain safe and effective treatments for adults and children 16 years and over.
Educating consumers and health care professionals about the association between the use of aspirin for viral illnesses in children and the development of Reye's syndrome was "pivotal" in reducing the use of aspirin in children.
The drug is already banned for under-12s because of links with Reye's Syndrome, a rare but potentially fatal condition which affects the liver and brain.
If youngsters are given aspirin during childhood there is a very small risk of them developing Reye's Syndrome, which is a condition affecting the liver and the brain but there is no connection to mothers taking it during pregnancy.
Also dangerous to chickenpox sufferers is Reye's syndrome, though it more often occurs after children are given aspirin to treat fever.
There is a strong connection between the serious disease, Reye's syndrome, and aspirin.
A word of caution: several studies have linked the use of aspirin to the development of Reye's syndrome in children recovering from influenza or chickenpox.
* Children and teenagers 6 months to 18 years of age on long-term aspirin treatment, who, if they catch influenza, could develop Reye's syndrome which causes coma, liver damage, and death
There is no role for antibiotic medications in managing uncomplicated colds[5,6-11] or preventing secondary bacterial infections[12]; the therapeutic effect of vitamin C in preventing or alleviating symptoms has been inconsistently demonstrated.[13-15] Some nonprescription medications relieve cold symptoms in older children and adults.[16,17] In particular, aspirin and nonsteroidal drugs reduce headache and sore throat pain.[2] Aspirin use in symptomatic children is contraindicated because of an association with Reye's syndrome.[29] Antihistamines reduce sneezing and nasal drainage;[5,20] decongestants reduce nasal secretions.[5,21] Coughing can be controlled with codeine.[4] Inhaling moist warm heat[22-24] and taking zinc[25-26] do not alter the course of a cold.
Wolfe: Raw milk, aspirin and Reye's Syndrome, tampons and toxic shock, Phenformin and lactic acidosis, Posicor and Duract are all instances where there was clear, unequivocal data at the FDA showing harm, but where the FDA failed to either ban a product or require necessary labeling.
Risks associated with aspirin include bleeding, gastric ulcers, tinnitis (earringing), Reye's syndrome (a rare complication usually in children with chicken pox and fin), and serious problems for some allergy and asthma sufferers.