Rose, Irwin

Rose, Irwin,

1926–2015, American biochemist, b. Brooklyn, N.Y., Ph.D. Univ. of Chicago, 1952. Rose was on the faculty of Yale Medical School from 1954 to 1963 and a senior member of the Fox Chase Cancer Center in Philadelphia from 1963 until 1995. After retiring he accepted (1997) a special appointment as a researcher at the Univ. of California, Irvine. In 2004 Rose shared the Nobel Prize in Chemistry with Aaron CiechanoverCiechanover, Aaron,
1947–, Israeli biochemist, M.D. Hebrew Univ.–Hadassah Medical School, Jerusalem, 1974; D.Sc. Technion (Israel Institute of Technology), Haifa, 1982. He has been on the faculty at the Technion since 1986.
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 and Avram HershkoHershko, Avram,
1937–, Israeli biochemist, M.D. Hebrew Univ.–Hadassah Medical School, Jerusalem, 1965, Ph.D. 1969. Hershko has been a professor at the Rappaport Faculty of Medicine at the Technion (Israel Institute of Technology), Haifa, since 1972.
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 for their discovery of ubiquitin-mediated protein degradation. The three scientists elucidated the pathway through which protein degradation takes place in cells, and identified the molecules called ubiquitins as markers that indicate what proteins are to be broken down. Cancer and some degenerative diseases are believed to result from disruptions in this pathway.
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