Immunohistochemical characterization of S100A6
in the murine ovary.
, S100A9, and S100A12 also have consistently high levels in samples of AD patients [135, 149].
binding protein and Siah-1 interacting protein (CacyBP/SIP): spotlight on properties and cellular function.
(calcyclin) is a calcium-binding protein of the S100 family, which has been isolated from melanocytes, Schwann cells, Langerhans cells, and dermal dendrocytes.
Genes of diverse functional groups and signaling routes appeared: Cytoskleleton (BCL7A, DYNC1L12, SEFT10, SEPT11), transcriptional and translational regulation (DEPDC1, GABPB1, LHFPL2, NFIB, POLR3C, RPL34, RPS3A, RPS21, RPS25, TFDP2, TRIM24, ZBTB1, ZBTB38, ZFP112), cell death (CASP2, INC2, MDM4, NAIP), DNA maintenance and processing (BAHCC1, FANCA, HIST1H3G, IK, KDM4C, MCM7, PRB3, RNASEH2B, SNRPE, TFDP2), signal transduction (ANXA2, ARHGAP19, C7orf47, CCDC50, DTX3, FHL2, P1K3CG, RALB, TICAM2), transport functions (ABCC1, FXYD2, S100A6
, SCNN1C, XP05), oxidative stress response (SPATS2L, GSTT2B, NQ01), blood coagulation (FGA, MATR3, PROCR, PIK3CG), and others (ADAM22, ALDH3A2, FAM161A, HDDC2, HLA-F).
The researchers then narrowed the molecules down to two proteins, S100A6
and S1009, which are most likely to appear in samples from patients with cancer but are absent from the other samples.
Asi, por ejemplo, en la interaccion con las proteinas S100B o S100A6
, una puede activar la via de la cinasa PI3/AKT y la otra la via de JNK, a pesar de que los ligandos pertenecen a la misma familia y son estructuralmente identicos (14).
Gene ontology: biological Genes p-Value process terms Cell cycle CCNB1, CCNB2, MNAT1, CDC2, 2.7 E-14 CDKN 1 A, CDKN3, CDKN2A, ANAPC1, CDK10 Cellular metabolism KRT15, KIF1B, ZNF697, 4.3E-13 PRG2, P2RY2,IMMP2L Growth factor and growth BMP-2, TCF[beta]1, VEGF, 1.2E-11 factor receptor activity BMP8B, CSF1, FCFR1, BMPR2, 1GF2R, PDCFB, TGFBR2, NRP1, CCR2 Biosynthetic process CEL, COL11A2, ACPP, MMP14, 1.8E-9 CACNB1, ALPL, CDH1, ITGA3, SERPINB10, TAF4B, ABCB10, IRF8 Cell proliferation ATF3, MK167, S100A6
, FTH1, DHCR7 2.1E-8 Signal transduction MAP2K3, MAPK14, MAP3K10, BAMBI, NDRG2, ECM1, SMAD7 5.5E-7 Apoptosis MYC, P53AIP1, ZBTB16, BBC3, 1.3E-5 VHL, CASP3, APITD1 Table 5 KEGG pathway analysis.
In the instance of background staining, S100A6
can be a good substitute, although weak nuclear and cytoplasmic staining for S100A6
can be seen in normal/reactive pancreatic ducts.
The individual members of the S100 protein family show a tissue- and cell-type-specific expression pattern; for example, there are high concentrations of S100B and S100A6
in the brain (6-8).
Possibly related to the onset of fibrosis was increased expression of calcyclin (S100a6
) (Figure 3C) a calcium-binding protein that is associated with metastasis and with the activation of hepatic stellate cells involved in the development of fibrosis and cirrhosis (Komatsu et al.
Detection of S100B, S100A6
and galectin-3 ligands in meningiomas as markers of aggressiveness.