Sjögren's syndrome

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Related to Sicca: sicca syndrome, rhinitis sicca

Sjögren's syndrome

[′shō·grənz ‚sin‚drōm]
(immunology)
An autoimmune disease characterized by the destruction of salivary and lacrimal glands, damage by T lymphocytes within the glands may be accompanied by damage by immune complexes throughout the body.
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Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca. Curr Eye Res.
Sicca symptoms(On direct questioning)###38.5%(n=10)###61.5%(n=16)
We also showed that sB2M can particularly distinguish pSS patients from those with sicca symptoms but no autoimmune disease.
These results were also confirmed by Manning et al., who compared tolerability of these dyes in patients and characteristics of ocular surface staining in keratoconjunctivitis sicca (39).
After examination for objective evidence of sicca complex by Schirmer test, TBUT and Ocular Staining Score (OSS), serological tests were performed.
Ocular manifestations (Table 2) were noted in 46 out of 100 patients (46%) and keratoconjunctivitis sicca was the common disease, being present in 40 patients (40%).
Its histopathologic hallmark is the periductal lymphocytic infiltrate with destruction of salivary and lacrimal glands resulting in loss of their function, which leads to sicca symptoms.
If left untreated, the condition can lead to severe complications including Kerato-conjunctivitis sicca (KCS).
In addition to xerostomia and keratoconjunctivitis sicca, Sjogren's syndrome may frequently be accompanied by arthralgia and myalgia and 85% of patients experience severe fatigue.
All healthy volunteers had a normal medical history and physical examination; had no symptoms of xerostomia or keratoconjunctivitis sicca; had no sialoadenitis or mass lesions in salivary glands; and were not using medications.
De este caracter deriva el epiteto especifico de Pecluma sicca (femenino del latin seccus, seco).
West Highland terriers, as they get older, are prone to keratoconjunctivitis sicca, commonly known as "dry-eye".