SIRTS


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SIRTS

Single Image Random Text Stereogram. (Or ASCII stereogram).
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The effect of SIRTs on epigenetics, intracellular pathways, and cytokines suggests that they play a role in the pathogenesis of RA (8, 9).
It has been documented that these anti-inflammatory SIRTs decrease the pro-inflammatory cytokine and chemokine levels and ameliorate experimentally induced arthritis (11, 12, 19).
Given the role of SIRTs in fundamental cell processes and protection from age related changes, the role of SIRT2 has begun to be studied in neurodegeneration.
As with other SIRTs, SIRT2 is [NAD.sup.+] dependent and is a potential redox sensor and studies have shown that SIRT2 enhances cell viability under oxidative stress and inhibition or knock-down of SIRT2 decreases intracellular ATP levels and enhances cell death.
Horikawa, "Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins," Molecular Biology of the Cell, vol.