are made and embedded in the membrane of the cellular compartment called the endoplasmic reticulum, or ER.
Aunque se conoce que esta es la principal via de regulacion de enzimas lipogenicas por algunos AGI que han sido estudiados, aun no se conoce con claridad si los AGI que ingresan en la MEC desencadenan directamente la via de la SREBP
(Figura 2 # 20) o si lo hacen de forma indirecta a traves del estimulo de hormonas como la leptina y la prolactina (Figura 2 #21) o ambos.
Professor Song discovered that SREBP
controls the biosynthesis of cholesterol, fatty acids and triglyceride.
Novel putative SREBP
and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice.
In addition, 8 genes (2 of SREBPs
and 6 of FABP4) were identified as superior to the remaining 23 genes (10 of SREBPs
and 13 of FABP4) based on a test of FAC and economic traits .
2] Nonstandard abbreviations: FFA, free fatty acids; DNL, de novo lipogenesis; SREBP
, sterol regulatory element binding protein; CoA, coenzyme A; SCD1, stearoyl-CoA desaturase-1; TG, triacylglycerides; DG, diacylglycerols; CE, cholesterol ester; PL, phospolipid.
superoxide dismutase; GPx, glutathione peroxidase; SDS-PAGE, sodium dodecylsulfate polyacrylamide gel; SREBP
, sterol regulatory element-binding protein; VCAM-1, vascular cell adhesion molecule 1; ICAM-1, intercellular adhesion molecule 1; NF-[kappa]B, nuclear factor-kappa B; PPAR[gamma], peroxisome proliferator-activated receptor gamma; MMP-9, matrix metalloproteinase 9; FRAP, ferric reducing/antioxidant power; AMPK, AMP-activated protein kinase.
The response to the reduction of intracellular sterol is mediated by transcription factor SREBP
SIRT1 also regulates lipid metabolism by manipulating PPAR-[alpha], LXR, FXR, and SREBP
signals [28, 29].
The researchers focused on two key regulators of lipid (fat) metabolism that are found in many human cells as well: SREBP
(sterol regulatory element-binding protein) that stimulates synthesis of fatty acids in the liver, and AMPK (adenosine monophosphate kinase) that turns SREBP
on and off.
Moreover, many nsSNPs were found in a set of 26 genes including FAT tumor suppressor homolog 3 (FAT3, 903 SNPs), family with sequence similarity 13, member A (FAM13A, 94 SNPs), ATP-binding cassette, subfamily G (ABCG2, 92 SNPs) and SREBP
cleavage activating protein (SCAP, 69 SNPs), in which the relationship of the genes with milk production was not previously reported (Supplementary Table 2).
Fat accumulation in Caenorhabditis elegans is mediated by SREBP