A role for PPARalpha in the control of SREBP
activity and lipid synthesis in the liver.
Goldstein, "The SREBP
pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor," Cell, vol.
Liu et al., "Sterol-responsive Element-binding Protein (SREBP
) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: A novel role of SREBP
in regulating cholesterol metabolism," The Journal of Biological Chemistry, vol.
Using RTPCR, expression of PPAR[gamma] (d), STAT5A (e), and SREBP
1c (f) was established.
Six weeks after the drug treatment of the Apo[E.sup.-/-] mice fed with a high-fat diet, the mRNA expressions of Insig, PAQR3, SCAP, and SREBP
in the aorta, liver, and adipose tissue of the TMP group mice were significantly decreased as compared to the control group (P < 0.01), with no significant difference between the two drug-treatment groups (P > 0.05) (Figure 4).
The PCSK9 gene mRNA is sterol regulated by the sterol receptor element binding proteins (SREBPs
) SREBP-la and -2.
Tweaking the components of the cycle again, they engineered cells to keep SREBP
in the ER while allowing SCAP to move to the Golgi on its own.
This produces defective SREBP
sensing, increased HMG CoA reductase activity and cholesterol synthesis.
Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR and SREBP
One way through which proteasome inhibition by PIs can contribute to liver damage involves a regulatory molecule called sterol regulatory element-binding protein (SREBP
(sterol regulatory element-binding protein) that stimulates synthesis of fatty acids in the liver, and AMPK (adenosine mono-phosphate kinase) that turns SREBP
on and off.They found that second-hand smoke exposure inhibits AMPK activity, which, in turn, causes an increase in activity of SREBP