sterol regulatory element binding protein

(redirected from Srebp)
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sterol regulatory element binding protein

[¦ste‚rȯl ¦reg·yə·lə‚tȯr·ē ‚el·ə·mənt ′bīnd·iŋ ‚prō‚tēn]
(biochemistry)
A transcription factor required for the active transcription of genes that encode the low-density lipoprotein receptor and enzymes in cholesterol synthesis.
References in periodicals archive ?
A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver.
Goldstein, "The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor," Cell, vol.
Liu et al., "Sterol-responsive Element-binding Protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: A novel role of SREBP in regulating cholesterol metabolism," The Journal of Biological Chemistry, vol.
Six weeks after the drug treatment of the Apo[E.sup.-/-] mice fed with a high-fat diet, the mRNA expressions of Insig, PAQR3, SCAP, and SREBP in the aorta, liver, and adipose tissue of the TMP group mice were significantly decreased as compared to the control group (P < 0.01), with no significant difference between the two drug-treatment groups (P > 0.05) (Figure 4).
The PCSK9 gene mRNA is sterol regulated by the sterol receptor element binding proteins (SREBPs) SREBP-la and -2.
Tweaking the components of the cycle again, they engineered cells to keep SREBP in the ER while allowing SCAP to move to the Golgi on its own.
This produces defective SREBP sensing, increased HMG CoA reductase activity and cholesterol synthesis.
Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR and SREBP signaling.
One way through which proteasome inhibition by PIs can contribute to liver damage involves a regulatory molecule called sterol regulatory element-binding protein (SREBP)-1.
SREBP (sterol regulatory element-binding protein) that stimulates synthesis of fatty acids in the liver, and AMPK (adenosine mono-phosphate kinase) that turns SREBP on and off.They found that second-hand smoke exposure inhibits AMPK activity, which, in turn, causes an increase in activity of SREBP.
El gen de las enzimas lipogenicas que actuan en la glandula mamaria contiene un extremo SRE (Figura 2 #16) al que se unen las SREBP. Ante la ausencia de un estimulo desencadenante, la SREBP se encuentra conformando un complejo con la proteina SCAP (SREBP cleavage activating protein; proteina activante del rompimiento de las SREBP) en el RE.