salicylate

(redirected from Salicylates)
Also found in: Dictionary, Thesaurus, Medical.

salicylate

(səlĭs`əlāt'), any of a group of analgesicsanalgesic
, any of a diverse group of drugs used to relieve pain. Analgesic drugs include the nonsteroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, acetaminophen, narcotic drugs such as morphine, and synthetic drugs with morphinelike action such as meperidine
..... Click the link for more information.
, or painkilling drugs, that are derivatives of salicylic acid. The best known is acetylsalicylic acid, or aspirinaspirin,
acetyl derivative of salicylic acid (see salicylate) that is used to lower fever, relieve pain, reduce inflammation, and thin the blood. Common conditions treated with aspirin include headache, muscle and joint pain, and the inflammation caused by rheumatic fever and
..... Click the link for more information.
. Now often made synthetically, they were originally derived from salicin, the active ingredient in willow bark, used for centuries in the treatment of pain and fever. Salicylates also occur naturally in many plants used as foods (e.g., strawberries, almonds, tomatoes). Methyl salicylate is the main component of wintergreen, sweet birch, gautheria, and betula oils; the compound is used in rubbing linimentsliniment,
liquid preparation rubbed on skin, used to relieve muscular aches and pains. It contains some substance that when rubbed over the affected part causes mild irritation and often brings more blood to the painful part.
..... Click the link for more information.
 to soothe muscular aches and as a flavoring. Sodium salicylate, traditionally used in the treatment of arthritis, is also used in dyes and as a nonedible preservative.

In general, salicylates, especially aspirin, are used medically to reduce fever and inflammation and to relieve headache, menstrual pain, and pain in nerves, muscles, and joints. Because of the effects of salicylates on blood platelets and clotting, aspirin is often prescribed prophylactically for those at risk of stroke or heart attack. Salicylates are useful, relatively safe drugs, but normal doses can cause gastrointestinal disturbances in sensitive patients and large doses can be toxic or fatal, especially to children.

salicylate

[sə′lis·ə‚lāt]
(organic chemistry)
A salt of salicylic acid with the formula C6H4(OH)COOM, where M is a monovalent metal; for example, NaC7H5O3, sodium salicylate.
References in periodicals archive ?
Products containing salicylate include but are not limited to aspirin and PeptoBismol.
Analgesics, including aspirin, were the most common etiology of all drug poisonings in the USA, with salicylate poisoning leading to a fatal outcome in 34 patients out of 2113 deaths reported in 2013 [54].
Excipients: methyl salicylate, menthol, triclosan, propylene glycol, isopropyl alcohol and deodorized mixture of butane and propane-values not specified in the package insert (BIOFENAC, 2006).
Once a rat met the criteria for at least 4 consecutive baseline days they were injected with either a 200 mg/kg (i.p.) dose of sodium salicylate dissolved in 50 mg/mL saline or an equivalent volume of saline 2 h before testing.
Clinical chemistry laboratory records between January 2006 and June 2007 were reviewed to identify all patients for whom blood salicylate levels had been requested.
I., Gasull E., Encapsulation of methyl and ethyl salicylates by beta-cyclodextrin HPLC, UV-vis and molecular modeling studies.
Although the negative side effects of prolonged high-dose aspirin intake, which include potentially life threatening gastrointestinal bleeding, preclude its chronic use in patients with type 2 diabetes, the clinical confirmation that salicylates improve insulin resistance has prompted an examination of safer salicylate forms for efficacious treatment.
Such things as rehydration and insulin for diabetic ketoacidosis and removal of salicylate in salicylate overdose are common examples.
Jane Hersey says, "Fortunately, not every person with food sensitivities will react to salicylates. Some people will react to several salicylates; others may have a problem with only one.
Many patients with ulcerative colitis who are receiving ineffective treatment with a salicylate also take an antidiarrheal drug, as well as other motility-inhibiting drugs such as antiemetics or even narcotics.
Despite these uncertainties, evidence exists to suggest that significant amounts of salicylates are being consumed.
Cherries--Rich in anthocyanins and salicylates, cherries may have anti-inflammatory properties similar to aspirin, a salicylate derivative.