salicylate

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salicylate

(səlĭs`əlāt'), any of a group of analgesicsanalgesic
, any of a diverse group of drugs used to relieve pain. Analgesic drugs include the nonsteroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, acetaminophen, narcotic drugs such as morphine, and synthetic drugs with morphinelike action such as meperidine
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, or painkilling drugs, that are derivatives of salicylic acid. The best known is acetylsalicylic acid, or aspirinaspirin,
acetyl derivative of salicylic acid (see salicylate) that is used to lower fever, relieve pain, reduce inflammation, and thin the blood. Common conditions treated with aspirin include headache, muscle and joint pain, and the inflammation caused by rheumatic fever and
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. Now often made synthetically, they were originally derived from salicin, the active ingredient in willow bark, used for centuries in the treatment of pain and fever. Salicylates also occur naturally in many plants used as foods (e.g., strawberries, almonds, tomatoes). Methyl salicylate is the main component of wintergreen, sweet birch, gautheria, and betula oils; the compound is used in rubbing linimentsliniment,
liquid preparation rubbed on skin, used to relieve muscular aches and pains. It contains some substance that when rubbed over the affected part causes mild irritation and often brings more blood to the painful part.
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 to soothe muscular aches and as a flavoring. Sodium salicylate, traditionally used in the treatment of arthritis, is also used in dyes and as a nonedible preservative.

In general, salicylates, especially aspirin, are used medically to reduce fever and inflammation and to relieve headache, menstrual pain, and pain in nerves, muscles, and joints. Because of the effects of salicylates on blood platelets and clotting, aspirin is often prescribed prophylactically for those at risk of stroke or heart attack. Salicylates are useful, relatively safe drugs, but normal doses can cause gastrointestinal disturbances in sensitive patients and large doses can be toxic or fatal, especially to children.

salicylate

[sə′lis·ə‚lāt]
(organic chemistry)
A salt of salicylic acid with the formula C6H4(OH)COOM, where M is a monovalent metal; for example, NaC7H5O3, sodium salicylate.
References in periodicals archive ?
During the visit, she was counseled on this being early influenza season and the avoidance of salicylate products since the 1980s in children, with the exception of cardiac uses.
Animals were randomly assigned into two groups (even numbers GDD and odd numbers GSM): group subjected to the application of aerosol containing diclofenac diethylammonium (GDD: 9 animals for the cutaneous tissue, and 9 animals for the subcutaneous), and group subjected to the aerosol with methyl salicylate (GSM: 9 animals for the cutaneous tissue, and 9 animals for the subcutaneous).
The maximum up regulation of OsPAL after methyl jasmonate and methyl salicylate application was 10 and 12 times higher at 12 h, respectively as compared to control plants.
In the current paper we show that, in contrast to exercise or metformin which increase AMPK activity by altering the cells energy balance, the effects of salicylate is totally reliant on a single Ser108 amino acid of the beta 1 subunit.
A qualitative assessment of the salicylate content of the medicine indicated a 2+ level of salicylate.
Encapsulation of methyl and ethyl salicylates by beta-cyclodextrin HPLC, UV-vis and molecular modeling studies.
Objectives: This study aims to investigate and compare the effectiveness of diclofenac sodium phonophoresis (DSPH), methyl salicylate phonophoresis (MSPH) and conventional therapeutic ultrasound (TUS) in patients with knee osteoarthritis (OA).
Instead, sodium salicylate and other nonacetylated salicylates, including salsalate, inhibit the activity of the transcription factor NF-[kappa]B (33).
They use substances such as methyl salicylate (wintergreen oil), camphor, menthol and capsaicin (the substance that gives chili peppers their spiciness) to dilate blood vessels in the skin, triggering warming, cooling or other sensations at the skin's surface.
Cochrane researchers, who looked at data from 16 studies looking at creams containing painkiller salicylate, found no proven benefits.
As with Movelat, the rubefacient compounds in many of these products are salicylates, which, while they are related to aspirin, may not work in the same way, especially when applied to the skin.
Metabolic acidosis can also occur by poisoning from ethanol, methanol, ethylene glycol or salicylates.