Sanlúcar de Barrameda (sänlo͞o`kär dā bärämā`thä), city (1990 pop. 56,375), Cádiz prov., S Spain, at the mouth of the Guadalquivir River, in Andalusia. It is a port shipping sherry from nearby Jerez. It is the site of a popular resort. Sanlúcar flourished after the discovery of America when all ships passed it to reach Seville. Columbus sailed from Sanlúcar in 1498, and Magellan in 1519. A medieval castle, the palace of the dukes of Medina Sidonia, and a 14th-century church are of interest.