Secretin


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secretin

[si′krēt·ən]
(biochemistry)
A basic polypeptide hormone produced by the duodenum in response to the presence of acid; acts to excite the pancreas to activity.

Secretin

 

a hormone substance (tissue hormone) secreted by the mucosa of the upper portion of the small intestine that participates in the regulation of pancreatic secretion. Secretin was discovered in 1902 by the British physiologists W. Bayliss and E. Starling. (Starling introduced the concept of the hormone into science in 1905 as a result of his study of secretin.)

Chemically, secretin is a peptide consisting of 27 amino-acid residues, 14 of which are in the same sequence as in glucagon. Secretin is obtained in a pure form from the intestinal mucosa of swine. It is released mainly under the influence of the hydrochloric acid of gastric juice, which enters the duodenum with chyme, a gruel-like material. Secretion can be induced experimentally by introducing dilute acid into the small intestine.

Secretin is absorbed by the blood and travels to the pancreas, where it intensifies the secretion of water and electrolytes, especially bicarbonate. Secretin increases the volume of pancreatic juice secreted but does not affect the production of pancreatic enzymes. The latter function is performed by pancreozymin, a substance elaborated in the intestinal mucosa. The biological determination of secretin is based on its ability to make the pancreatic juice more alkaline when injected intravenously into animals. Secretin has been synthesized chemically.

REFERENCES

Clegg. C., and A. Clegg. Gormony, kletki, organizm, ch. 13. Moscow, 1971. (Translated from English.)
Gastrointestinal Hormones. Stuttgart, 1972.

A. A. BULATOV

References in periodicals archive ?
We believe that, this is the first report on the expression and purification of the secretin domain of the Pil[Q.sub.380-706] protein with a His-tag in bacterial expression system.
(7-17) Intervention Effectiveness (SOR *) Effective Early intensive behavioral therapy (7) A Melatonin (for sleep disturbance) (8) A Parent-mediated early intervention (9) A Risperidone (for behavioral issues) (10) A Inadequate evidence to support Acetylcholinesterase inhibitors (14) B Acupuncture (11) B Atypical antipsychotics (12) B Auditory integration therapy (13) A B6-magnesium supplementation (14) B Gluten-free/casein- free diet (15) A Music therapy (13) A Naltrexone (14) B Omega-3 fatty acids (16) A Ineffective Secretin IV-17 A ASD, autism spectrum disorder; IV, intravenous; SOR, strength of recommendation.
Hu, "K-ras mutations in duodenal aspirate without secretin stimulation for screening of pancreatic and biliary tract carcinoma," Cancer, vol.
Therefore, the second aim of the present study was to investigate whether secretin and glucagon have any effect on a rat model of retinal ischemia.
(1986) Immunoglobulin in secretin. Journal of Medical Technology 30(9), 971-979.
Uremia is associated with high plasma levels of pancreatic secretagogue peptides as secretin, gastrin, and an abnormal pancreatic juice composition with decreased bicarbonate and amylase.
Xu et al., "Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist," Biochemistry, vol.50, no.38, pp.
Among the other 15 papers in these proceedings are discussions of extragastrointestinal functions and the transcriptional regulation of secretin and secretin receptors, PACAP as a master regulator of neuroendocrine stress circuits and the cellular stress response, the development of the zebrafish hypothalamus, the behavioral effect of neuropeptides related to feeding regulation in fish, and what lies ahead for the proprotein convertases.
371) do not discuss the experiments of Banting and Best, they do discuss how the hormone secretin is produced by the mucous membrane of the intestine and is carried by the blood to the pancreas, where it stimulates the secretion of pancreatic juice.
These cells can be classified as open or closed according to apical communication with the lumen (SANTOS; ZUCOLOTO, 1996); in argyrophillic and argentaffin cells by the capacity to retain and reduce silver salts (GRIMELIUS; WILANDER, 1980); and in hormone producing cells (insulin, secretin, somatostatin and others), principally based on the characteristics and content of their secretory granules (POLAK et al., 1993).
The activity of these secretory proteins may be diverse, for example, the EpsD secretin from V.
Increased sympathetic nervous system output and increased expression of multiple hormones including vasoactive intestinal polypeptide, gastrin, secretin, and motilin during exercise commonly manifest in the athlete as lower gastrointestinal distress.