Secretin


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Related to Secretin: cholecystokinin, CCK, secretin test

secretin

[si′krēt·ən]
(biochemistry)
A basic polypeptide hormone produced by the duodenum in response to the presence of acid; acts to excite the pancreas to activity.

Secretin

 

a hormone substance (tissue hormone) secreted by the mucosa of the upper portion of the small intestine that participates in the regulation of pancreatic secretion. Secretin was discovered in 1902 by the British physiologists W. Bayliss and E. Starling. (Starling introduced the concept of the hormone into science in 1905 as a result of his study of secretin.)

Chemically, secretin is a peptide consisting of 27 amino-acid residues, 14 of which are in the same sequence as in glucagon. Secretin is obtained in a pure form from the intestinal mucosa of swine. It is released mainly under the influence of the hydrochloric acid of gastric juice, which enters the duodenum with chyme, a gruel-like material. Secretion can be induced experimentally by introducing dilute acid into the small intestine.

Secretin is absorbed by the blood and travels to the pancreas, where it intensifies the secretion of water and electrolytes, especially bicarbonate. Secretin increases the volume of pancreatic juice secreted but does not affect the production of pancreatic enzymes. The latter function is performed by pancreozymin, a substance elaborated in the intestinal mucosa. The biological determination of secretin is based on its ability to make the pancreatic juice more alkaline when injected intravenously into animals. Secretin has been synthesized chemically.

REFERENCES

Clegg. C., and A. Clegg. Gormony, kletki, organizm, ch. 13. Moscow, 1971. (Translated from English.)
Gastrointestinal Hormones. Stuttgart, 1972.

A. A. BULATOV

References in periodicals archive ?
Synthetic human secretin, manufactured under the brand name ChiRhoStim[TM], was approved by the FDA in 2004 for the stimulation of pancreatic secretions to help diagnose pancreatic exocrine dysfunction, stimulation of gastrin secretion to help diagnose gastrinoma, and facilitation of the identification of the ampulla during ERCP.
As shown in Figure 2, the secretion of the serum GIH ghrelin, CCK, and secretin was closely related to [alpha]-amylase activity in the duodenum.
Food and Drug Administration has granted orphan drug designation to its synthetic human secretin, RG1068, for use with magnetic resonance imaging (MRI) of the pancreas.
the biotech company seeking to develop secretin for use against autism, announced the disappointing results of its latest trial, which involved 132 children.
The FDA has granted SecreFlo(TM) Orphan Drug Designation, which means that it is the only form of secretin marketed for the approved indications in the United States until 2009.
There are several studies on Secretin that have been done in a blinded manner and in none has any significant effect been documented.
These hormones include gastrin, secretin, cholecystokinin, somatostatin, gastricinhibitory polypeptide (GIP), and vasoactive intestinal peptide (VIP).
Spence is the lead investigator at UCLA for a national clinical trial for the drug secretin, which has shown promise for a certain subgroup of autistic patients.
Secretin is FDA-approved for use in the diagnosis and treatment of certain gastrointestinal diseases but its instant notoriety for its effects on children with autism has sparked a series of investigations with mixed results (Rimland, 1999; Sandier et al.
One of the latest is injections of porcine secretin.
The most recent example of this approach involves use of secretin, a hormone that stimulates secretions of the pancreas.