A recent meta-analysis dealing with the reliability of the ESC to measure sudomotor or sensory nerve fiber
function has questioned this test.
We found that HFD-fed mice displayed significant thermal hyperalgesia, thus implying small sensory nerve fiber
lesions [7, 20].
At age 15 weeks, rats were weighed, blood samples for glucose measurements were taken from the tail vein, and assessment of motor and sensory nerve conduction velocities (MNCVs and SNCVs, respectively) and small sensory nerve fiber
function was performed.
To reduce spasticity, the neurosurgeon will cut some of the tiny rootlets that make up each sensory nerve fiber
. Rootlets of motor nerves will not be cut, because this would prevent the muscles from receiving messages from the brain, leaving them with no tone--soft and unresponsive.
The cornea is the most densely innervated tissue in the body, so corneal nerve assessment is extremely sensitive for detecting small sensory nerve fiber
damage as compared to other tests including measurement of intra-epidermal nerve fibers in the skin, notes lead investigator Joseph L.
These mice have sensory nerve conduction deficits, small sensory nerve fiber
neuropathy, and intraepidermal sensory nerve fiber
CNTX-4975 is designed to induce a localized degeneration of pain sensing fibers without affecting other sensory nerve fibers
. In January 2018, CNTX-4975 received Fast Track designation by the U.S.
We suggest that mast cell degranulation plays a key role in vasodilation and vascular permeability associated with activation of trigeminal sensory nerve fibers
in the dura mater where is the origin of migraine pain.
Surgical intervention includes the interruption of a major group of cervical and uterine sensory nerve fibers
, known as pelvic denervation.
The surgery would involve cutting some of the sensory nerve fibers
that come from the muscles and enter the spinal cord, including the potential removal of several vertebrae..
Local application of capsaicin or RTX to human skin or bladder (intravesicular) resulted in reductions in nerve fibers and loss of TRPV1 functions [15-19], suggesting that the defunctionalizing effect of the TRPV1 agonists was caused by loss of TRPV1-expressing primary sensory nerve fibers
The results show that the transplanted stem cells act as a "bridge" which allows injured sensory nerve fibers
to grow into the spinal cord, rebuild functional nerve connections, and thereby achieve long term restoration of major parts of the lost sensory functions.