There are different mechanisms for controlling serine protease
activity to avoid any unwanted protein degradation and to allow spatial and temporal regulation of proteolytic activity.
TMC435350 is a potent inhibitor of the hepatitis C virus (HCV) NS3/4A serine protease
and is presently in a phase IIa proof-of-concept trial (OPERA- 1) in Europe.
Recently, three other members of this family, hK6 (also known as neurosin), hK10 [also known as normal epithelial cell specific 1 (NES1)], and hK11 [also known as trypsin-like serine protease
(TLSP)], have been shown to be potential biomarkers for ovarian and prostate cancer (4-6).
The two posters are titled "Results of a phase I placebo-controlled trial in healthy volunteers to examine safety, tolerability and PK of the protease inhibitor TMC435350 after single and repeated dosing" and "In vitro activity and preclinical PK of a potent HCV NS3/4A serine protease
Experimental evidence has also shown that hK2 and hK4 can activate the proform of another serine protease
, uPA (44, 50).
DPP4 is a serine protease
that has emerged as an important target for the treatment of type 2 diabetes.
Molecular cloning and characterization of prostase, an androgen-regulated serine protease
with prostate-restricted expression.
proteinase k is a broad-spectrum serine protease
that can hydrolyse keratin.
Anti-plasma serine protease
inhibitor (SERPINA5), hepatocyte growth factor activator (HGFAC), anti-leucine zipper protein 4 (LUZP4), and anti-phosphoinositide phospholipase C (PLCH2) were used (Abcam, USA).
The plant protease inhibitor (PI) interaction with serine proteases
in insects from a stable and inactive acyl-enzyme distort the serine protease
active site (catalytic triad).
Molecular cloning, characterization and expression analysis of a chymotrypsin-like serine protease
from kuruma shrimp Marsupenaeus japonicus.
Patients who improved the most on doxycycline also had the lowest activity of serine protease
and matrix metalloprotease (MMP) in their skin, reported Anna Di Nardo, MD, PhD, of the University of California San Diego in La Jolla.