serine protease

(redirected from Serine proteinase)

serine protease

[¦se‚rēn ′prōd·ə‚ās]
(cell and molecular biology)
A family of endopeptidases whose proteolytic activity involves the hydroxy group of the serine residue; they play an important role in digestion, blood clotting, and the complement system.
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References in periodicals archive ?
The most successful procedure to date involved the use of a broad-spectrum serine proteinase inhibitor called Futhan (31-35).
Proteolytic activity, in turn, is often provided by enzymes that belong to the class of serine proteinase, such as trypsinlike and chymotrypsinlike enzymes.
Alpha 1-proteinase is the main neutral serine proteinase in serum, especially Elastase, which enjoys three different additional Oligo-Saccharides, and it is 12% of its weight.
Elastase, a serine proteinase released by activated human neutrophils, can degrade a wide variety of biomacromolecules including elastin, and is considered a marker of inflammatory diseases.
High-molecular-weight serine proteinase from lobster muscle that degrades myofibrillar proteins.
Enrymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors.
The serine proteinase trypsin also activates secretion of gastric but not duodenal mucus via PAR-2 receptors and, pretreatment of rats with the agonist for PAR-2 prevents gastric injury promoted by indomethacin, ethanol or acid (Kawabata et al.
Upon release into the circulation, it is cleaved by the serine proteinase furin into the biologically active 32-amino acid BNP, which is the C-terminal fragment, and the inactive 76-amino acid N-terminal (NT) proBNP.
Plasmin, the major native milk serine proteinase, is an important contributor to proteolytic breakdown in milk and dairy products.
Serine proteinase inhibitors have been reported to block host cell invasion by both T.
Viron's current product development pipeline consists of: serine proteinase Inhibitors (VT-100 Series), chemokine binding proteins (VT-200) and cytokine binding proteins (VT-300 Series).
6]-dependent enzymes; (2) the novel use of steric effects as a general strategy to block processing of serine acyl enzyme intermediate and hence irreversibly inhibit serine proteinase targets such as elastase; (3) clinical trials of transglutaminase inhibitors as a treatment for acne; (4) the invention of quiescent affinity labels which has essentially revolutionized the affinity label concept.

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