The most successful procedure to date involved the use of a broad-spectrum serine proteinase
inhibitor called Futhan (31-35).
Proteolytic activity, in turn, is often provided by enzymes that belong to the class of serine proteinase
, such as trypsinlike and chymotrypsinlike enzymes.
Alpha 1-proteinase is the main neutral serine proteinase
in serum, especially Elastase, which enjoys three different additional Oligo-Saccharides, and it is 12% of its weight.
Elastase, a serine proteinase
released by activated human neutrophils, can degrade a wide variety of biomacromolecules including elastin, and is considered a marker of inflammatory diseases.
High-molecular-weight serine proteinase
from lobster muscle that degrades myofibrillar proteins.
Enrymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase
The serine proteinase
trypsin also activates secretion of gastric but not duodenal mucus via PAR-2 receptors and, pretreatment of rats with the agonist for PAR-2 prevents gastric injury promoted by indomethacin, ethanol or acid (Kawabata et al.
Upon release into the circulation, it is cleaved by the serine proteinase
furin into the biologically active 32-amino acid BNP, which is the C-terminal fragment, and the inactive 76-amino acid N-terminal (NT) proBNP.
Plasmin, the major native milk serine proteinase
, is an important contributor to proteolytic breakdown in milk and dairy products.
inhibitors have been reported to block host cell invasion by both T.
Viron's current product development pipeline consists of: serine proteinase
Inhibitors (VT-100 Series), chemokine binding proteins (VT-200) and cytokine binding proteins (VT-300 Series).
6]-dependent enzymes; (2) the novel use of steric effects as a general strategy to block processing of serine acyl enzyme intermediate and hence irreversibly inhibit serine proteinase
targets such as elastase; (3) clinical trials of transglutaminase inhibitors as a treatment for acne; (4) the invention of quiescent affinity labels which has essentially revolutionized the affinity label concept.