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The division of biological science concerned with antigen-antibody reactions in serum. It properly encompasses any of these reactions, but is often used in a limited sense to denote laboratory diagnostic tests, especially for syphilis. The techniques of blood grouping have come from the study of antigen-antibody reactions in serum, as have techniques for identification of genetic polymorphism and quantitation of numerous serum proteins. With these advances came the means for developing transfusion therapy with cells and plasma. In addition, these techniques led to identification of antibodies involved in incompatibility reactions, such as in erythroblastosis fetalis, and the development of effective measures to prevent their occurrence. Further, extension of these techniques to identification of antigens on white cells led to effective methods of histocompatibility typing, facilitating organ transplantation. See Transplantation biology



the study of the properties of blood serum; the term “serology” is usually applied to the branch of immunology that studies serum antibody-antigen interactions.

Serologic reactions may be direct (two-component), for example, agglutination, passive hemagglutination, and precipitation, or they may be indirect (three-component), for example, microbial neutralization and hemagglutination retardation. Several simple reactions may constitute complex serologic reactions, including bacteriolysis and complement fixation. Immunofluorescence, which is based on the staining of antibodies (antigens) with fluorochromes, is also widely used. A special type of serologic reaction is the immobilization of motile microorganisms, for example, the immobilization of Treponema pallidum during syphilis. Certain serologic studies are not carried out in vitro but are administered directly to experimental animals; for example, the animals are given immune serum in serial dilutions and a lethal dose of microbes.

Serologic reactions are used for scientific and diagnostic purposes in infectious and noninfectious immunology, for example, in the transfusion of blood, in the determination of blood groups, and in the establishment of generic and individual protein specificity. Serologic investigations are also employed in epidemiology and epizootiology in identifying the source of an infection, the method of the transmission of an infection, the state of immunity in humans and animals, and the effectiveness of vaccination. The antigen-antibody reaction constitutes the basis of seroprophylaxis and serotherapy. Today, serology is concerned with highly specific diagnostic and therapeutic serums—with the development of methods for their production, with the evaluation of their activity, and with the clarification of their action.


Reznikova, L. S., R. V. Epshtein-Litvak, and M. I. Levi. Serologicheskie metodv issledovaniiapri diagnostike infeklsionnykh boleznei. Moscow, 1962.
Handbook of Experimental Immunology. Oxford, 1967.



The branch of science dealing with the properties and reactions of blood sera.
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We obtained more insight into the effect of changes in definitions of positive serology and case definitions for reporting on serologic and reported data.
The contract is for the supply of reagents, cells, control materials and consumables and supplies to carry out research in the field of serology transfuzjologicznej (including the lease of the analyzer system and back up system) for the Independent Institute Transfuzjologicznej Serology Section CZMP proceedings ZP / 5/2015.
The virology /microbiology department at great ormond street is looking for a fully automated random serology analyser for the detection of antigen and antibody.
Viral serology was done by complement fixation method at Virology Department.
Among the Coxsackie serology positive patients 9/15 had ejection fraction > 45 (60.
Ethnicity had no significant effect on the prevalence of positive coeliac serology (p=0.
Historically, as in other areas of laboratory medicine, clinician requests for serology tests have been handwritten onto pre-printed request forms.
95%), while the leishmania serology was positive in 36/47 cases (76.
Non invasive tests particularly serology are usually preferred for diagnostic purpose as they are cost effective and convenient.
In an editorial note accompanying the MMWR report on the first confirmed case of HIV transmission from a living donor reported since 1989, the CDC said the report "highlights the need for repeat HIV screening for all living donors using a combination of HIV serology and NAT, as close to the time of organ donation as logistically feasible, to rule out acute or recent HIV infection in living donors before organ donation.
provides a textbook for clinical laboratory students and practicing laboratorians and other allied health professionals that introduces immunology principles and serology techniques commonly used in the laboratory.
Birds were inoculated with either a killed virus vaccine or a plasmid-mediated DNA WNV vaccine, and postinoculation serology was evaluated.