Recently, molecular epidemiology investigations have been conducted on random samples of the Seveso
population highly exposed to TCDD (zones A and B) and from the reference noncontaminated area (non-ABR) to evaluate how TCDD exposure affects the AhR pathway in human subjects in vivo (Baccarelli et al.
(1)Directive 2003/105/EC or amended Seveso
The results of this study of women residing in Seveso
, Italy, in 1976 at the time of an explosion that released high levels of TCDD provide little evidence of an association of exposure and age of menarche.
The best-known dioxin accident took place in Seveso
, Italy, in 1976.
About noon on Saturday, 10 July 1976, an explosion at the ICMESA chemical plant near Seveso
, Italy, approximately 25 km north of Milan, exposed the nearby residents to the highest known residential exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) (Mocarelli et al.
1991) and in residential populations in Chapaesk, Russia, and Seveso
, Italy, who received high-level TCDD exposure (Revich et al.
French Green Party politicians immediately demanded a reform of legislation governing industrial sites classed on the Seveso
scale, which prompted junior Industry Minister Nicole Fontaine to announce that current regulations concerning explosives would be amended if necessary.
The second breach concerns the transposition of Directive 96/82/EC on limiting the consequences of major accidents involving dangerous substances, known as the Seveso
The data used in the regression analysis include observations obtained for groups ranging from 19 individuals (Ranch Hand Group R4) to 15,000 individuals (Seveso
Zone R females).
The activities of the plant, which has been called Seveso
2, has been a source of pollution for many years, a fact which the authorities have recognised.
Such reports have been submitted under the Seveso
I Directive (82/501/EEC) with the most recent one being published on January 31, 2002.