Sheehan's syndrome


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Related to Sheehan's syndrome: Asherman's syndrome

Sheehan's syndrome

[′shē·ənz ‚sin‚drōm]
(medicine)
Pituitary necrosis caused by insufficient blood supply to the gland due to copious blood loss or intravascular clotting and hemorrhage associated with premature separation of the placenta during childbirth. Also known as postpartum pituitary necrosis.
References in periodicals archive ?
The most common etiology was Sheehan's syndrome (35.7%).
Prevalence of hypopituitarism: A study conducted in a tertiary care center in India reports most common cause of hypopituitarism to be a non-functioning pituitary adenoma followed by Sheehan's syndrome (27%).11 As we have excluded sellar and parasellar tumors, which remains the commonest cause, we found that 35.7% of hypopituitarism was attributable to Sheehan's syndrome, which is close to a Turkish study (107 of 388 patients; 27.6%).12 Sheehan's syndrome also accounted for the cause of hypopituitarism in 41% (15/22) of women in our study.
In fact, there have been some case reports where patients with Sheehan's syndrome recover back to normal less than 1 year after the event [20, 21].
Recent studies suggest that autoimmunity plays a major role in the pathophysiology of Sheehan's syndrome. In fact, De Bellis et al.
The lactation failure is common and the lack of the prolactin response to administration of TRH has been suggested as a sensitive test for screening of patients with suspicion of Sheehan's syndrome. (12) The most common electrolyte abnormality encountered is hyponatremia, seen in 33% to 69% of all cases.
These findings on MRI characterize Sheehan's syndrome and provide early confirmation of the clinical diagnosis.
Also majority of patients with Sheehan's syndrome do not have hyperprolactinemia in spite of severe central hypothyroidism.
In summary, a case of Sheehan's syndrome associated with hyperprolactinemia is reported.
DISCUSSION: Sheehan's Syndrome presents with clinical signs and symptoms of deficiencies of gonadotropins, cortisol, thyroid and prolactin.
Whereas hypopituitarism associated with pituitary tumors often presents in an incomplete form, in Sheehan's syndrome the opposite is true.
Sheehan's syndrome refers to postpartum hypopituitarism as a result of pituitary necrosis occurring during severe hypotension or shock secondary to massive bleeding during or just after delivery.