Simon Flexner

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Related to Shigella flexneri: Salmonella typhimurium, Shigella sonnei

Flexner, Simon,

1863–1946, American pathologist, b. Louisville, Ky., M.D. Univ. of Louisville, 1889; brother of Abraham FlexnerFlexner, Abraham,
1866–1959, American educator, b. Louisville, Ky., grad. Johns Hopkins, 1886. After 19 years as a secondary school teacher and principal, he took graduate work at Harvard and at the Univ. of Berlin.
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. He served with the Rockefeller Institute (now Rockfeller Univ.) from 1903 to 1935 (as its first director, 1920–35) and was Eastman professor at Oxford from 1937 to 1938. He worked on experimental epidemiology and venoms and is known especially for his serum treatment of cerebrospinal meningitis and for his studies of poliomyelitis. He also isolated a bacillus of dysentery.

Flexner, Simon

(1863–1946) microbiologist, medical administrator; born in Louisville, Ky. (brother of Abraham Flexner). After researching and teaching as a pathologist at Johns Hopkins (1890–99), he went to the University of Pennsylvania (1899–1903); during this period he took time away to isolate a strain of the dysentery bacillus in the Philippines (1899) and to investigate the bubonic plague in San Francisco (1901). He joined the newly created Rockefeller Institute for Medical Research in 1901 to direct the research laboratories but soon became the institute's de facto administrator; he served as its official director from 1924–35. He was the editor of the Journal of Experimental Medicine (1904–23), and during World War I he was commissioned in the Army Medical Corps and charged with inspecting its medical laboratories in Europe. He made several other important contributions to his field, including developing a serum for cerebrospinal meningitis (1907) and laying the groundwork for the development of polio vaccines. He wrote The Evolution and Organization of the University Clinic (1939).
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Decreased susceptibility to antimicrobials among Shigella flexneri isolates in Manipal, South India--a 5 year hospital based study.
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However, Pseudomonas aeruginosa, Staphylococcus aureus and Shigella flexneri were more intensively under inhibitory effects of chorionic membrane which was not observed by Parthasarathy et al.
The organism was identified as Shigella flexneri and confirmed with Shigella flexneri antiserum (Wellcome diagnostics).
Sequence and molecular characterization of a multicopy invasion plasmid antigen gene ipaH of Shigella flexneri.
Published in the academic journal eLife, the team sequenced the DNA of Shigella flexneri from samples taken from Africa, Asia, South and Central America, along with samples dating as far back as 1913.
Ongoing outbreak of Shigella flexneri serotype 3a in men who have sex with men in England and Wales, data from 2009-2011.
Shigella flexneri strains were isolated from stools of patients suffering from diarrhoea admitted in different hospitals of Azad Kashmir (Pakistan) over a 5-year period.
A new multiplex PCR for differential identification of Shigella flexneri and Shigella sonnei and detection of Shigella virulence determinants.
Asimismo, hubo disminucion de la frecuencia de Shigella flexneri en los trimestres observados.
Avaliacao da atividade antimicrobiana- A avaliacao da atividade antimicrobiana dos extratos foi realizada frente as cepas de Bacillus cereus, Enterococcus faecalis, Escherichia coli, Klebisiella pneumoniae, Salmonella choleraesuis, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus epidermidis [ATCC 12228] e um isolado clinico de Staphylococcus aureus resistente a meticilina (MRSA).