An interesting Cyprus connection is that Shikimic Acid
is to be found in two of our native plants, Pistacia lentiscus, the mastic tree, and Opuntia ficus-indica, the prickly pear.
Compound rt (min) PDA rt (min) QqQ Hydroxybenzoic acids (1) Shikimic acid
1.50 2.35 (2) Protocatechuic acid 5.99 6.80 (3) 4-Hydroxybenzoic acid 8.05 8.82 (4) Vanillic acid 9.04 9.82 (5) Syringic acid 9.31 10.06 Hydroxycinnamic acids (6) Quinic acid 1.51 2.28 (7) Chlorogenic acid 7.51 8.30 (8) Caffeic acid 9.09 9.85 (9) Coumaric acid 11.07 11.79 (10) Sinapic acid 11.65 12.36 (11) Ferulic acid 11.73 12.43 (12) 4,5-Dicaffeoylquinic 11.75 12.45 acid Xanthones (13) Mangiferin 8.83 9.62 Flavonols (14) Rutin 10.86 11.62 (15) Isoquercitrin 11.34 12.10 (16) Quercetin 15.25 16.01 (17) Kaempferol 17.16 17.89 Flavanones (18) Naringin 12.07 12.82 (19) Naringenin 16.86 17.53 Flavones (20) Linarin 12.43 13.22 (21) Luteolin 15.08 15.85 (22) Acacetin 16.08 17.03 (23) Apigenin 16.68 17.38 [[lambda].sub No.
Biosynthetically, the B-ring and linking three-carbon chain (C6-C3) are the phenylpropanoid skeleton that is derived from the shikimic acid
pathway, while the other C-6 (A-ring) is an acetate pathway origin that bears the three hydroxyl groups spaced at meta positions from each other within the benzene ring.
Gao, "Antibacterial activity of shikimic acid
from pine needles of Cedrus deodara against Staphylococcus aureus through damage to cell membrane," International Journal of Molecular Sciences, vol.
We have come up with new indigenous processes of shikimic acid
production for large- scale validation.
Rap biosynthesis in media enriched with different concentrations of shikimic acid
pumila secondary metabolites due to increase in substrates to the shikimic acid
is a white crystalline cyclitol, which is a precursor material for industrial synthesis of the important drug, oseltamivir phosphate (Tamiflu), which is an effective drug againstthe H5N1 influenza virus , especially if administered early.
It covers chirality, topology, and asymmetric synthesis; asymmetric synthesis; sugars; amino acids, peptides, and proteins; nucleosides, nucleotides, and nucleic acids; polyketides; terpenes; shikimic acid
derivatives; and alkaloids.
These compounds are allelochemicals which are usually the secondary or waste products of main plants methabolic pathways specially shikimic acid
and acetate pathways .
coli of shikimic acid
, the starter molecule for production of oseltamivir, marketed as Tamiflu, for treatment of severe influenza (Johansson et al., 2005).