sialic acid

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sialic acid:

see glycoproteinglycoprotein
, organic compound composed of both a protein and a carbohydrate joined together in covalent chemical linkage. These structures occur in many life forms; they are prevalent and important in mammalian tissues.
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Sialic Acid


any of the monobasic polyhydroxy amino acids that are derivatives of neuraminic acid. Sialic acids are colorless crystalline solids that dissolve readily in water but are insoluble in nonpolar solvents. They decompose without melting in the temperature range 130°-200°C and are easily decomposed by the action of acids and bases. In nature, as components of glycoproteins and glycolipids, sialic acids are found in, among other places, the cell walls of animals, nerve tissue, and mucous secretions. The biosynthesis of biopolymers containing sialic acids is carried out using the activated form of sialic acids, namely, cytidine monophosphate-sialic acids, which are special sialyltransferase enzymes. Sialic acids determine the antigen and receptor properties of cell surfaces, participating in the interaction of the surfaces with, for example, viruses, toxins, and hormones.

sialic acid

[sī′al·ik ′as·əd]
Any of a family of amino sugars, containing nine or more carbon atoms, that are nitrogen- and oxygen-substituted acyl derivatives of neuraminic acid; as components of lipids, polysaccharides, and mucoproteins, they are widely distributed in bacteria and in animal tissues.
References in periodicals archive ?
Terminal sialic acid can be linked in ([alpha]2-3) or ([alpha]2-6) linkage and can be assigned on guidance of the structural reporter groups [H-3.
Mucous membrane cells, such as those that line the internal airways of the lungs, nose and throat, defend themselves against such pathogens by secreting a mucus rich in sialic acids - a gooey trap intended to bog down viral particles before they can infect vulnerable cells.
Lysosomal sialidase (neuroaminidase) cleans sialic acid residues located in the last part of gangliosides, oligosaccharides and glycoproteins.
We used hemadsorption assays to investigate the direct interaction of viruses with sialic acids.
To discard a polymorphic variant of Tf, selected samples were digested with neuraminidase from Clostridium perfringens to remove the negatively charged terminal sialic acid residues.
Such effects of EDTA would explain both the low total protein content of our EDTA extract and its low content of glycoproteins, especially those bearing sialic acids.
Dotting the surfaces of most cells in all animals, sialic acids influence cell-cell interactions but can also serve as docking stations for microorganisms that infect cells.
Sialic acids (Sia) are a blooming and challenging area of research, followed by many laboratories around the world.
Epithelial cells of the human upper respiratory tract contain mostly [alpha]2,6-linked sialic acids (SA[alpha]2,6) and low levels of [alpha]2,3-linked sialic acids (SA[alpha]2,3) (3).