silent mutation


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Related to silent mutation: genetic code, Nonsense mutation

silent mutation

[′sī·lənt myü′tā·shən]
(genetics)
A mutation that does not result in amino acid sequence change.
References in periodicals archive ?
Earlier it was reported that though it is silent mutations the heterozygous EGFR mutation (G/A genotype) group showed higher sensitivity (lower IC50 values) to gefitinib than the EGFR wt (G/G genotype) group did (Hsieh et al.
Our results for spectrum of b thalassaemia mutations are in agreement with other studies across the country10,17 which show the predominance of FR 8-9 and IVSI-5 mutation in Punjabis and Pathans and CAP+1 as the commonest silent mutation.
Of the four silent mutations 42 (ag), 138 (c [right arrow] t), 231 (c [right arrow] a) and 237 (g [right arrow] c) detected in this study, 237 (g [right arrow] c) is novel.
The mutation 2466 C [right arrow] T was a silent mutation.
Of the HFE variants (1 in 1000 samples) T189C (6), a silent mutation, is present in 88% of the variants.
Of the 4 specimens positive by DHPLC but negative by sequencing, APEX detected base changes in 3, including 1 specimen with 2 mutations (a 1-bp substitution in intron 5 and a silent mutation at codon 147; see Table 4 of the online Data Supplement).
All Haarlem strains carried one characteristic silent mutation in mutT3 and one characteristic mutation in ogt (Ser 15 replaced by Thr).
Other silent mutations are known to alter mRNA processing, and in the RET gene in particular, the silent mutation 16471, interferes with normal transcription, leading to decreased protein concentrations (39).
This 438G-->A sequence change is a silent mutation because both the wild-type ACA and the mutated ACG triplet encode for threonine at residue 146 of the GAMT peptide (T146T).
G3357A and T3394C are missense mutations (Met17Ileu and Tyr30His, respectively), and C3375A is a silent mutation.
In addition to the G238C transition discriminating for the TPMT*2 allele, further polymorphisms are known in exon 5, one silent mutation (C339T) and one mutation that produces a stop codon (G292T), which discriminates for the TPMT*3D allelic variant (Fig.
Minor] mutation site, the nucleotide sequence analysis revealed a silent mutation (G3315A) located 10 nucleotides upstream from the [Fin.