Patterns of single-nucleotide polymorphisms
in candidate genes for blood-pressure homeostasis.
They examined genotypes for 393,000 single-nucleotide polymorphisms
, looking for mutations that might be statistically linked to diabetes.
Evaluation of 19 single-nucleotide polymorphisms
in three genes within the chromosome 9q linkage region showed that Alzheimer's disease was significantly associated with two single-nucleotide polymorphisms
in UBQLN1 and one in APBA1.
The fragments containing the nine single-nucleotide polymorphisms
(SNPs) were amplified in one sevenplex and one duplex PCR reaction (Table 1).
The researchers scanned each chromosome at short, regular intervals to locate and identify tiny variations in genetic sequences--called single-nucleotide polymorphisms
(SNPs)--among the participants.
* Environmental Genome Project--This project comprises discovery and resequencing of single-nucleotide polymorphisms
, the Comparative Mouse Genomics Centers Consortium, and programs in molecular epidemiology and bioethics.
We are now witnessing the third generation of genome mapping, based on single-nucleotide polymorphisms
(SNPs), and analyzed by PCR and chip-based microarrays (3).
The first phase of this project identifed more than 20,000 single-nucleotide polymorphisms
(SNPs) in 217 environmentally relevant candidate genes; the goal is to resequence and analyze for SNPs in a total of 554 genes.
Partly because of the ability to examine a greater number of samples faster than ever before, researchers are no longer looking at single-nucleotide polymorphisms
The scientists analyzed the genomes of 502 German male and female melanoma patients and 450 healthy control subjects, looking for single-nucleotide polymorphisms
(SNPs) that might be significantly associated with elevated risk of sporadic melanoma.
Presenters discussed strategies in help researchers decide where in concentrate their research dollars and energy among the more than 7.2 million genetic variations and single-nucleotide polymorphisms
(SNPs) cataloged by the HGP.