Jip

(redirected from Smad4)
Also found in: Medical.

Jip

Dora’s little pet, lives in a tiny pagoda. [Br. Lit.: Dickens David Copperf eld]
See: Dogs
References in periodicals archive ?
Association of SMAD4 mutation with patient demographics, tumor characteristics, and clinical outcomes in colorectal cancer.
The researchers used RT-PCR and qRT-PCR of cancer-related SMAD4 gene to validate the microarray data.
Activating point mutations in KRAS are an early genetic alteration in the development of MCN, whereas inactivation of TP53 and SMAD4 occur as late events.
The analysis centered on the activity of the KRAS, CDKN2A, SMAD4, and TP53 genes.
This study analysed protein expression and DNA alterations for the KRAS, CDKN2A, SMAD4, and TP53 genes by immunohistochemistry and next-generation sequencing in formalin-fixed, paraffin-embedded tumors in 356 patients with resected pancreatic adenocarcinoma who were treated at the Dana-Farber/Brigham and Women's Cancer Centre in Boston, University of Rochester Medical Centre, and Stanford Cancer Institute.
Genes Tested AtP ALK APC ATM BAP1 BRCA2 BRIP1 BUB1B CDC73 CDH1 CEP57 CHEK2 CYLD DDB2 DICER1 ERCC3 ERCC4 ERCC5 EXT1 EXT2 FANCD2 FANCE FANCF FANCG FANCI GATA2 GPC3 HNF1A HOXB13 HRAS MLH1 MHS2 MSH6 MUTYH NBN PHOX2B PMS1 PMS2 PPM1D PRF1 RAD51D RBI RECQL4 RET RHBDF2 SDHC SDHD SLX4 SMAD4 SMARCA4 TP53 TSC1 TSC2 VHL WT1 BARD1 BLM BMPR1A BRCA1 CDK4 CDKN1C CDKN2A CEBPA DI53L2 EGFR EPCAM ERCC2 EZH2 FANCA FANCB FANCC FANCL FANCM FH FLCN KIT MAX MEN1 MET NF1 NF2 NSD1 PALB2 PRKAR1A PTCH1 PTEN RAD51C RUN XI SBDS SDHAF2 SDHB SMARCB1 STK11 5UFU TMEM127 WRN XPA XPC This chart shows all 98 cancer susceptible genes included in this new test.
Activated Smad1/5/8 forms a hetero-oligomer with a common Smad, Smad4, and then this complex translocates into the nucleus to initiate the transcription of its target genes.
In silico analysis of SMAD4 involved in hepatocellular carcinoma.
sup][7] Both Smad2 and Smad3 are activated by TGF-[sz], myostatin, or activin whereas Smad1, Smad5, and Smad8 are activated by bone morphogenetic proteins; the activation of these proteins results in the interaction with Smad4, leading to the modulation of target gene expression.
Other frequently found mutations in CIN include those in KRAS, P53, SMAD4 and PIK3CA [86].
SMAD4 Mutations Produce Aggressive Schwarzenegger Tumors