encephalomalacia

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encephalomalacia

[en¦sef·ə·lō·mə′lā·shə]
(medicine)
Infarction of the brain.
Any softening or fragmentation of the brain.
References in classic literature ?
I have often observed that the Season as it goes on produces a kind of softening of the brain. However, I think anything is better than high intellectual pressure.
By undue action, development and concentration, the brain begets upon the system and character a high state of excitability and inflammation often resulting in later life, and sometimes in middle age, in the condition of softening of the brain. It is a terribly malady, not so much for its amount of suffering as for the pitiable condition to which it reduces the most collossal [sic] intellect.
Let's see: his father died (from "softening of the brain") when he was four; his brother Joseph (barely two) six months later.