spastic paraplegia


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spastic paraplegia

[′spas·tik ‚par·ə′plē·jə]
(medicine)
Paralysis of the lower limbs with increased muscular tone and hyperactive tendon reflexes; commonly seen in diseases and injuries involving pyramidal tracts of the spinal cord.
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In the light of neurological findings normal imaging studies and family history of difficulty in walking in a sibling suspicion of familial spastic paraplegia was made and family's neurological assessment was requested.
A novel splice site mutation in ERLIN2 causes hereditary spastic paraplegia in a Saudi family.
Blackstone, "Cellular pathways of hereditary spastic paraplegia," Annual Review of Neuroscience, vol.
A few disorders, including CMT 4F, myotonia congenita, and spastic paraplegia type 4, were associated with costs of -$2000.
Multiple sclerosis, B12 deficiency, human T-cell lymphotrophic virus-1 infection, structural inflammatory lesions of the spinal cord, motor neuron disease, and hereditary spastic paraplegia have been excluded.
CARDIFF: Captain Beany will be running in the Power House Marathon in Cardiff today to raise money for nineyear-old Dana Twomey, who suffers from hereditary spastic paraplegia.
Pre-clinical work has shown Neuralstem's cells to extend the life of rats with ALS (as reported in the journal TRANSPLANTATION, October 16, 2006, in collaboration with Johns Hopkins University researchers), and also to reverse paralysis in rats with Ischemic Spastic Paraplegia (as reported in NEUROSCIENCE, June 29, 2007, in collaboration with researchers at University of California San Diego).
There was just a thought she may say no but I'm delighted she didn't", said Roo, who suffers from what is known as Spordadic Hereditary Spastic Paraplegia.
Many mutations for the motor axon degeneration disease, hereditary spastic paraplegia (HSP), affect proteins that model ER shape.
The company's cells recently reversed paralysis in some rats with Ischemic Spastic Paraplegia in a study conducted at the University of California at San Diego, and published in the journal NEUROSCIENCE.
Because of gradually increasing problems with mobility due to a condition known as hereditary spastic paraplegia, I was advised by a neurologist that the next step (pardon the pun) was a wheelchair.
The Company is targeting major central nervous system diseases including: Ischemic Spastic Paraplegia, Traumatic Spinal Cord Injury, Huntington's disease and Amyotrophic Lateral Sclerosis (ALS), often referred to as Lou Gehrig's disease.