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A primitive male germ cell, the last generation of which gives rise to spermatocytes.



a developing male sexual cell during the period of division prior to growth. Spermatogonia are in a state of rapid mitotic division. Primary and secondary spermatogonia are distinguished in insects and certain other invertebrates; secondary spermatogonia, the smaller of the two types, are surrounded by cells that form the seminal vesicle, or spermatocyst. Mammals have two types of spermatogonia, which differ in degree of differentiation and in chromatinic structure. The duration of the period of division varies from one animal species to another, depending on the number of generations and the rate of division of spermatogonia—parameters that are constant for eachspecies. Spermatogonia are formed in the parietal layer of the seminiferous tubules. Many animals have a specific zone of division in the cecum of the testes.

References in periodicals archive ?
Biomanipulation of bovine spermatogonial stem cells. Anim Reprod 2008;5(l/2): 16-22.
Conclusion: According to positive effects of collagen and growth factors on the colonisation of spermatogonial stem cells, it seems that using the cells may lead to better colonisation of this type of stem cells.
Spermatogonial stem cells (SSCs) of the testis serve as a source pool for the continuous process of spermatogenesis and preserve fertility across nearly the whole lifetime of male mammals [1].
Subsequently, gonocytes are located in the basement membrane of seminiferous tubule and differentiate into spermatogonial stem cells (SSCs) (de Rooij and Grootegoed, 1998; Brinster, 2002).
Background: Niche cells, regulating Spermatogonial Stem Cells (SSCs) fate are believed to have a reciprocal communication with SSCs.
Transgenerational effects of di-(2-ethylhexyl) phthalate on testicular germ cell associations and spermatogonial stem cells in mice.
"In this study, we found that impairment of STAT3 signalling enhances spermatogonial stem cell self-renewal without affecting general proliferation of the cells.
Chapter 37 discusses the future of spermatogonial stem cell technology to repopulate the testes.
Culturing human spermatogonial stem cell had not been reported until 2009 that Sadri et al were able to propagate the Human Spermatogonial Stem Cells In vitro (11).
Spermatogonial stem cell self-renewal requires OCT4, a factor down-regulated during retinoic acid-induced differentiation.