Lee et al., "Sphingosine
1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells," Biochemical and Biophysical Research Communications, vol.
Biodiversity of sphingoid bases ("sphingosines
") and related amino alcohols.
Pyne, "Translational aspects of sphingosine
1phosphate biology," Trends in Molecular Medicine, vol.
As mentioned above, all sphingolipids are metabolically interconnected; therefore, CerS generated by the a-SMase are subsequently degraded by the ceramidase to sphingosine
which can be phosphorylated to S1P that subsequently can activate different receptors.
pathway is a key cellular signaling pathway implicated in various cancers and functions of the immune system.
Erythrocytes store and release sphingosine
1-phosphate in blood.
FRIDAY, March 23, 2018 (HealthDay News) -- For patients with secondary progressive multiple sclerosis, the selective sphingosine
1-phosphate (S1P) receptor1,5 modulator, siponimod, is associated with reduced relative risk of confirmed disability progression, according to a study published online March 22 in The Lancet.
BS, including sphingosine
(SP) and sphingosine-1phosphate (S1P)[9, a biologically important class of compounds, have essential functions including regulation of cell growth, differentiation, proliferation, adhesion, migration, and apoptosis as well as inflammation and angiogenesis .
Zhou et al., "Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine
1-phosphate receptor 2," Hepatology, vol.
There are several ways to generate ceramide in mammalian cells (Figure 1): hydrolysis of sphingomyelin, de novo synthesis from palmitoyl-CoA and serine, catabolism of glucosylceramide and galactosylceramide, synthesis from sphingosine
and fatty acid, and dephosphorylation of ceramide-1-phosphate.
Briefly, [3-[sup.3]H]-sphingosine (D-erythro > 97%, 50 [micro]Ci, 1.85 MBq, PerkinElmer) was dissolved in DMEM-low glucose with 10% FBS to a final concentration of 2.4 nM sphingosine
, corresponding to 110.000 dpm/ml radioactivity.
The compounds, sphingosine
and dihydrosphingosine, were found to be at significantly lower concentrations in blood samples from multiple sclerosis patients.