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Enlargement of the spleen.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



in medicine, the enlargement of the spleen. Splenomegaly occurs with diseases of the spleen (tumors, cysts, abscesses), with general infections (sepsis, malaria, typhoid fever, typhus), with blood diseases (leukoses, lymphgranulomatos-es), and with liver diseases. The spleen is examined by palpation while the individual is lying on his side; it will not be felt if its size is normal.

Splenomegaly is often the first manifestation of blood disease. In such cases, splenic puncture is performed in order to make an accurate diagnosis. With chronic leukoses, the spleen may occupy most of the abdomen and weigh as much as 8 kg. Splenomegaly is accompanied by disruption of breathing, blood circulation, and the functions of adjacent organs, including the stomach, intestine, and left kidney. Disturbances of splenic blood circulation (thromboses), suppression of hematopoiesis (hypersplenism), and other complications may also occur. The condition is treated by surgically removing the spleen (splenectomy), by irradiating the spleen with gamma rays, and by administering cytostatics and corticosteroids.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Chronic arthritis in the adult associated with splenomegaly and leucopenia: a report of five cases of an unusual clinical syndrome.
Among all 85 patients with splenomegaly at their initial examination, 64 (75.3%) had at least one clinic visit (for any condition) >6 months after arrival.
The high rate of open splenectomy in our series could possibly be due to the lack of appropriate equipment during the early years of the study, lack of the necessary laparoscopic skills, and the fact that patients who present with massive splenomegaly are not amenable to laparoscopy.
We present a 46-year-old Caucasian male with a documented medical history of hereditary splenomegaly and thrombocytopenia since childhood.
The patient's systemic symptoms with splenomegaly with multiple hypodense splenic lesions raised high suspicion for a primary hematologic malignancy or a primary splenic tumor.
Computed tomography (CT) showed scattered focal pulmonary infiltrates, splenomegaly, and a markedly distended stomach without an obvious focus of mechanical obstruction (Figure 1).
In children, the most prominent characteristics are fever, splenomegaly, neurologic manifestations, anemia, and thrombocytopenia, those frequently require transfusion support.
screened for the children originating from malaria-endemic zones who were exhibiting fever, splenomegaly, or both for malaria, they found 2 infected children (3).
A CT scan of the abdomen and pelvis with and without contrast showed bilaterally enlarged calcified adrenal glands, hepatomegaly with fatty change, splenomegaly, and mild ascites (Figures 4-6).
Patients were examined for important signs like erythromelalgia, facial plethora, numbness and splenomegaly. Patients were examined for signs of arterial or venous thrombosis.
A 35-year-old female presented in the year 2007 with fever and mild splenomegaly. She was investigated and diagnosed as PMF and was found to have mutated CALR (Type 1) gene in 2015.