Squalene


Also found in: Dictionary, Medical, Wikipedia.

squalene

[′skwā‚lēn]
(biochemistry)
C30H50 A liquid triterpene which is found in large quantities in shark liver oil, and which appears to play a role in the biosynthesis of sterols and polycyclic terpenes; used as a bactericide and as an intermediate in the synthesis of pharmaceuticals. Also known as spinacene.

Squalene

 

an aliphatic polyunsaturated liquid hydrocarbon with the formula C30H50. Squalene, which boils at 242°C and is soluble in many organic solvents, is an important intermediate in the metabolism of triterpenoids and steroids and is widely distributed in the tissues of animals and plants, as well as in microorganisms. It was first isolated from the liver of the shark. The biosynthesis of squalene is from mevalonic acid, which is converted to farnesyl pyrophosphate. The latter, under the action of squalenesynthetase (in the presence of thiamine), is di-merized to yield squalene. The enzymatic conversion of squalene to lanosterol and of lanosterol to cholesterol and other sterols commences with the aerobic oxidation of the terminal double bond of squalene.

References in periodicals archive ?
Squalene and squalene analogs studied by several techniques and found useful in cancer therapy.
The global squalene market is estimated to reach a market size of USD 211.
Characterization of a squalene synthase from the Thraustochytrid microalga Aurantiochytrium spp.
Non-polar lipids like cholesterol, linolenic acid and squalene are present as a complex mixture in F.
Parenteral lipid emulsions in guinea pigs differentially influence plasma and tissue levels of fatty acids squalene cholesterol and phytosterols.
The 2000 to 50,000 number-average molecular weight polymer contains monocyclic heterocyclic groups such as diketopyrrolopyrrole, squalene, or carotene.
With rich ingredients including chamomile, dew grass and Tahitian seawater extract, apple stem cell and squalene, this is the perfect, at-home facial.
These authors showed that some gallates are potent inhibitors of the enzyme squalene epoxidase, which is involved in the biosynthesis of ergosterol [42] and, therefore, is essential for the survival of the microorganism.
Inhibition of squalene epoxidase by allylamines results in sterol deficiency in the fungal cell wall and also intracellular accumulation of squalene and finally fungal cell death.
Squalene is a major component of human skin lipid and is the single most abundant ozone-reactive constituent (Nicolaides, 1974).