Steinman, Ralph Marvin

Steinman, Ralph Marvin,

1943–2011, Canadian biologist, M.D. Harvard Medical School, 1968. He was a researcher and professor at Rockefeller Univ., New York City, from 1970 until his death in 2011. Steinman was awarded half of the 2011 Nobel Prize for Physiology or Medicine for his discovery in 1973 of the dendritic cell and its role in adaptive immunity; he shared the prize with Bruce A. BeutlerBeutler, Bruce Alan,
1957–, American immunologist and geneticist, b. Chicago, Ill., M.D. Univ. of Chicago, 1981. Beutler has been a professor and physician at Rockefeller Univ. (1984–86), a faculty member at the Univ.
..... Click the link for more information.
 and Jules A. HoffmannHoffmann, Ernst Theodor Amadeus
, 1776–1822, German romantic novelist and composer, a lawyer. At one time an opera composer and musical director at Bamberg and a gifted music critic, he is most famous as a master of the gothic tale.
..... Click the link for more information.
. Steinman showed that dendritic cells can sense signals from the body's innate immune response and then activate T lymphocytes, or T cells, a type of blood cell that protects the body from infection. This mechanism allows the immune system to fight off foreign pathogens without attacking the body's own cells. Steinman was diagnosed with pancreatic cancer in 2007, and he extended his own life using a dendritic-cell-based immunotherapy that he designed himself.
The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved.