"Corticosteroids are the current standard of care for adult Still's disease
. There are high needs for new therapies for inadequate responders and relapsed patients," said Dr.
LPIN2 gene mutation is believed to be associated with Majeed syndrome; however, we observed a case (case 13) that was more consistent with adult-onset Still's disease
. The patient presented with daily fevers, joint pain, and a macular rash, which are symptoms consistent with adult-onset Still's disease
The etiology of adult Still's disease
(ASD) is unknown; both genetic factors and a variety of infectious triggers have been suggested as important, but there has been no proof of an infectious etiology, and the evidence supporting a role for genetic factors has been mixed.
Although these classification criteria were validated for patients with sJIA, recent studies have shown that this classification is useful to identify MAS in patients with adult-onset Still's disease
and SLE [12,13].
Healthcare company Swedish Orphan Biovitrum AB (publ) (Sobi) stated on Wednesday that it has randomised the first patient to evaluate efficacy and safety of anakinra in the treatment of Still's disease
under the phase 3 study anaSTILLs.
It's a win-win for the Still's community." Boerner, a patient living with Still's Disease
, will also continue her advocacy efforts as a permanent advisor at IFAA.
Adult-onset Still's disease
presents with heterogeneous manifestations.
Both our cases were immunocompromised patients on treatment for pemphigus vulgaris and Still's disease
. Similarly, Riviere et al.
Seve, "Adult-onset Still's disease
," Autoimmunity Reviews, vol.
Persistent pruritic papules and plaques associated with adult-onset Still's disease
: report of six cases.
Swedish Orphan Biovitrum AB (publ) (Sobi), has initiated two clinical programs with Kineret (anakinra) in North America, with the aim of evaluating two new potential indications for Kineret where a significant need for alternative treatment options exists: acute gout and Still's disease