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Enlargement of the spleen.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



in medicine, the enlargement of the spleen. Splenomegaly occurs with diseases of the spleen (tumors, cysts, abscesses), with general infections (sepsis, malaria, typhoid fever, typhus), with blood diseases (leukoses, lymphgranulomatos-es), and with liver diseases. The spleen is examined by palpation while the individual is lying on his side; it will not be felt if its size is normal.

Splenomegaly is often the first manifestation of blood disease. In such cases, splenic puncture is performed in order to make an accurate diagnosis. With chronic leukoses, the spleen may occupy most of the abdomen and weigh as much as 8 kg. Splenomegaly is accompanied by disruption of breathing, blood circulation, and the functions of adjacent organs, including the stomach, intestine, and left kidney. Disturbances of splenic blood circulation (thromboses), suppression of hematopoiesis (hypersplenism), and other complications may also occur. The condition is treated by surgically removing the spleen (splenectomy), by irradiating the spleen with gamma rays, and by administering cytostatics and corticosteroids.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
We are working actively with Sumi Agro to support the full authorisation of Mevalone for use in the treatment of pome fruit storage disease, and we believe that this is achievable in the foreseeable future.'
Pompe disease (glycogen storage disease Type II, acid maltase deficiency, and OMIM #232300) is a rare, progressive, autosomal recessive metabolic disorder caused by a deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA).
New spectrophotometric assays of acid lipase and their use in the diagnosis of Wolman and cholesteryl ester storage diseases. Anal Biochem 1985;145:398-405.
Examples of metabolic diseases with hepatic presentation are tyrosinemia, Wilson's disease, progressive familial intrahepatic cholestasis (PFIC), Aagenaes syndrome, glycogen storage disease, non-alcoholic steatohepatitis (NASH)12-14.
Secondary diabetes mellitus: late complication of glycogen storage disease type 1b.
DISCUSSION: Pompe disease, also known as glycogen storage disease type II, is an inherited disorder whose primary symptom is progressive weakness in the muscles used for mobility and breathing.
Type I glycogen storage diseases: disorders of the glucose-6-phosphatase complex.
MPS I is one of the most common lysosomal storage diseases to affect the central nervous system, which in severe form can become Hurler syndrome.
The topics include a natural history of the cirrhotic patient, chronic portosystemic encephalopathy and its management, managing complications of liver transplantation, obesity and its hepatic complications in adults and children, and an approach to metabolic and storage diseases.
Lysosomal storage diseases are a group of rare, inherited diseases that initially result from defects in the lysosomc, a component of die cell that is responsible for the breakdown of certain molecules, such as complex lipids and sugars.