Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin
Without certain enzymes (matrilysin and stromelysin
) the macrophage cells cannot do their work.
Immunolocalization of stromelysin
, tumor necrosis factor (TNF) alpha, and TNF receptors in atrophied canine articular cartilage treated with hyaluronic acid and transforming growth factor beta.
Akiyama et al., "Matriptase activates stromelysin
(MMP-3) and promotes tumor growth and angiogenesis," Cancer Science, vol.
Marmer, "Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin
," The Journal of Biological Chemistry, vol.
Expression of MMP-10 (stromelysin
2) does not show any relationship with the advancement of bladder carcinoma , while expression of MMP-11 was significantly higher and positively correlated with the degree of tumor aggressiveness and malignancy .
is an activator of procollagenase.
MMP-7 and MMP-12 (stromelysin
, macrophage elastase) showed little or no expression in all specimens of our patients.
Gingival crevicular stromelysin
, collagenase and tissue inhibitor of metalloproteinase levels in healthy and diseased sites.
Regulation of Collagenase, Stromelysin
, and gelatinase B in human conjunctival and conjunctivochalasis fibroblasts by interleukin-1 beta and tumor necrosis factor-alpha.
We observed that EGCG was a strong inhibitor for MMP-2 and MMP-9 derived from cancer cells (20,21) and MMP-3 (stromelysin
(12.) Lohmander LS, Hoerrner LA, Dahlberg L, et al: Stromelysin
, tissue inhibitor of metalloproteinases and proteoglycan fragments in human knee joint fluid after injury.