Germline mutations and variants in the succinate dehydrogenase
genes in Cowden and Cowden-like syndromes.
-ve: negative; +ve: positive; [sup.18]F-FDOPA: [sup.18]F-fluorodihydroxyphenylalanine; PHEO: pheochromocytoma; PGL: paraganglioma; A: adrenaline; D: dopamine; NA: noradrenaline; FH: fumarate hydratase gene; HIF2A: hypoxia-inducible factor 2 alpha gene; MAX: Myc-associated protein X gene; NF1: neurofibromatosis type 1 gene; PHD1: prolyl hydroxylase domain protein 1 gene; RET: rearranged during transfection gene; SDHA: succinate dehydrogenase
subunit A gene; SDHA: succinate dehydrogenase
subunit A protein; SDHB: succinate dehydrogenase
subunit B gene; SDHB: succinate dehydrogenase
subunit B protein; SDHC: succinate dehydrogenase
subunit C gene; SDHD: succinate dehydrogenase
subunit D gene; VHL: von Hippel- Lindau gene.
 Nonstandard abbreviations: OMIM, Online Mendelian Inheritance in Man; TCA, tricarboxylic acid; IDH, isocitrate dehydrogenase; SDH, succinate dehydrogenase
; FH, fumarate hydratase; PHD, prolyl hydroxylase domain protein; HIF, hypoxia-inducible factor; NRF2, nuclear factor (erythroid-derived 2)-like 2; NQO1, NAD(P)H:quinone oxidoreductase 1.
But the activity of succinate dehydrogenase
was similar in both groups.
Figure 6: Succinate dehydrogenase
activity, triglyceride, interleukin 6 (IL6), and reactive oxygen species (ROS) concentrations, and hematoxylin and eosin staining in liver of ApoE KO mice treated with 0.15% cholesterol diet and Aster glehni extract.
Analysis of data showed a decrease in succinate dehydrogenase
(SDH) activity by 1.5- and 2.6-times in group 2 and group 3, respectively, compared to group 1 (control) (Table 2).
Partial inhibition of brain succinate dehydrogenase
by 3-nitropropionic acid is sufficient to initiate striatal degeneration in rat.
The activities of the citric acid cycle enzymes like succinate dehydrogenase
, isocitrate dehydrogenase and the activity of cytochrome c oxidase the enzyme of the electron transport chain is known to be inhibited by cypermethrin (Reddy and Yellamma, 1991a).
The hydrolytic enzymes such as Protease (EC 184.108.40.206), Amylase (EC 3.21.1) and respiratory enzymes such as Peroxidase (EC 220.127.116.11), Polyphenoloxidase (EC 18.104.22.168), Succinate dehydrogenase
(EC 22.214.171.124) and nitrate reductase (126.96.36.199) were studied in eighteen different macroalge belonging to three different species such as Chlorophyceae, Phaeophyceae and Rhodophyceae.
Liver and muscle mitochondria were isolated and assayed for the activities of succinate dehydrogenase
(13) and isocitrate dehydrogenase (18).
The capacity of classic markers for mitochondrial density, ie, the capacity of citrate synthase (CS) and succinate dehydrogenase
(SDH), as well the capacity of cytochrome c oxidase (COX) and beta-hydroxyacyl-CoA dehydrogenase (HAD), was determined in homogenized muscle biopsy samples obtained from the vastus lateralis muscle of nonexercising healthy young (age 20 [+ or -] 2 yr) subjects (31 women, 7 men).
3NP has long been known to inhibit succinate dehydrogenase
activity of the Krebs cycle and the respiratory chain in mitochondria.