suicide inhibitor

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suicide inhibitor

[′sü·ə‚sīd in′hib·əd·ər]
(biochemistry)
A compound which resembles the normal substrate for an enzyme, but which interacts with the enzyme to form a covalent bond and thus inactivates the enzyme.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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The topics covered in the subsequent chapters include characterization of enzyme activity by the equilibrium and steady-state models; reversible, irreversible, and mechanism-based (alternate and suicide inhibition) enzyme inhibition; effects of pH on enzyme reactions; mechanisms of enzyme reactions; two- and multisubstrate reactions; immobilized, interfacial, and allosteric enzymes; transient phases of enzyme reactions; and enzyme stability.